Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Novel roles of complement in systemic lupus erythematosus - Hypothesis for a pathogenetic vicious circle

Sturfelt, Gunnar LU ; Bengtsson, Anders LU ; Klint, Cecilia LU ; Nived, Ola LU ; Sjöholm, Anders LU and Truedsson, Lennart LU (2000) In Journal of Rheumatology 27(3). p.661-663
Abstract

We propose that impaired complement function enhances a pathogenetic vicious circle in SLE. In this process, induction and clearance of apoptotic cells is central. Apoptosis could be triggered by various etiological factors, such as infection, UV light, and drug reactions. Clearance of apoptotic material is reduced when complement function is impaired. Apoptosis leads to increased exposure of nuclear antigens to the immune system, to which estrogenic hormones could contribute. This could in turn lead to activation of autoreactive B cells, autoantibody production, and immune complex formation, all of which is accelerated by hypocomplementemia. Immune complexes may, at least partly via complement dependent mechanisms, accelerate... (More)

We propose that impaired complement function enhances a pathogenetic vicious circle in SLE. In this process, induction and clearance of apoptotic cells is central. Apoptosis could be triggered by various etiological factors, such as infection, UV light, and drug reactions. Clearance of apoptotic material is reduced when complement function is impaired. Apoptosis leads to increased exposure of nuclear antigens to the immune system, to which estrogenic hormones could contribute. This could in turn lead to activation of autoreactive B cells, autoantibody production, and immune complex formation, all of which is accelerated by hypocomplementemia. Immune complexes may, at least partly via complement dependent mechanisms, accelerate apoptosis.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Rheumatology
volume
27
issue
3
pages
661 - 663
publisher
Journal of Rheumatology Publishing Company Limited
external identifiers
  • pmid:10743804
  • scopus:0034102539
ISSN
0315-162X
language
English
LU publication?
no
id
7ade91a0-96ea-427c-be45-3b4f6972bdb4
date added to LUP
2019-05-23 10:20:41
date last changed
2024-03-19 08:31:21
@article{7ade91a0-96ea-427c-be45-3b4f6972bdb4,
  abstract     = {{<p>We propose that impaired complement function enhances a pathogenetic vicious circle in SLE. In this process, induction and clearance of apoptotic cells is central. Apoptosis could be triggered by various etiological factors, such as infection, UV light, and drug reactions. Clearance of apoptotic material is reduced when complement function is impaired. Apoptosis leads to increased exposure of nuclear antigens to the immune system, to which estrogenic hormones could contribute. This could in turn lead to activation of autoreactive B cells, autoantibody production, and immune complex formation, all of which is accelerated by hypocomplementemia. Immune complexes may, at least partly via complement dependent mechanisms, accelerate apoptosis.</p>}},
  author       = {{Sturfelt, Gunnar and Bengtsson, Anders and Klint, Cecilia and Nived, Ola and Sjöholm, Anders and Truedsson, Lennart}},
  issn         = {{0315-162X}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{661--663}},
  publisher    = {{Journal of Rheumatology Publishing Company Limited}},
  series       = {{Journal of Rheumatology}},
  title        = {{Novel roles of complement in systemic lupus erythematosus - Hypothesis for a pathogenetic vicious circle}},
  volume       = {{27}},
  year         = {{2000}},
}