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Effect of ciprofloxacin on human lymphocytes - Laboratory studies

Forsgren, A. LU ; Bredberg, A. LU and Riesbeck, K. LU orcid (1989) In Scandinavian Journal of Infectious Diseases, Supplement 21(60). p.39-45
Abstract

4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [3H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus... (More)

4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [3H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus the effects are very contradictory. Increased IL-2 may contribute to CNS side effects.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases, Supplement
volume
21
issue
60
pages
39 - 45
publisher
Scandinavian University Press
external identifiers
  • scopus:0024308664
  • pmid:2667107
ISSN
0300-8878
language
English
LU publication?
yes
id
7b0ea08d-9d58-4ed1-be81-1780c168f3d9
date added to LUP
2019-03-27 14:15:42
date last changed
2024-01-01 00:13:47
@article{7b0ea08d-9d58-4ed1-be81-1780c168f3d9,
  abstract     = {{<p>4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [<sup>3</sup>H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus the effects are very contradictory. Increased IL-2 may contribute to CNS side effects.</p>}},
  author       = {{Forsgren, A. and Bredberg, A. and Riesbeck, K.}},
  issn         = {{0300-8878}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{60}},
  pages        = {{39--45}},
  publisher    = {{Scandinavian University Press}},
  series       = {{Scandinavian Journal of Infectious Diseases, Supplement}},
  title        = {{Effect of ciprofloxacin on human lymphocytes - Laboratory studies}},
  volume       = {{21}},
  year         = {{1989}},
}