Effect of ciprofloxacin on human lymphocytes - Laboratory studies
(1989) In Scandinavian Journal of Infectious Diseases, Supplement 21(60). p.39-45- Abstract
4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [3H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus... (More)
4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [3H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus the effects are very contradictory. Increased IL-2 may contribute to CNS side effects.
(Less)
- author
- Forsgren, A. LU ; Bredberg, A. LU and Riesbeck, K. LU
- organization
- publishing date
- 1989-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases, Supplement
- volume
- 21
- issue
- 60
- pages
- 39 - 45
- publisher
- Scandinavian University Press
- external identifiers
-
- pmid:2667107
- scopus:0024308664
- ISSN
- 0300-8878
- language
- English
- LU publication?
- yes
- id
- 7b0ea08d-9d58-4ed1-be81-1780c168f3d9
- date added to LUP
- 2019-03-27 14:15:42
- date last changed
- 2024-01-01 00:13:47
@article{7b0ea08d-9d58-4ed1-be81-1780c168f3d9, abstract = {{<p>4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxocity tests with 4-quinolones are probably 'false' positive due to an increased [<sup>3</sup>H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus the effects are very contradictory. Increased IL-2 may contribute to CNS side effects.</p>}}, author = {{Forsgren, A. and Bredberg, A. and Riesbeck, K.}}, issn = {{0300-8878}}, language = {{eng}}, month = {{01}}, number = {{60}}, pages = {{39--45}}, publisher = {{Scandinavian University Press}}, series = {{Scandinavian Journal of Infectious Diseases, Supplement}}, title = {{Effect of ciprofloxacin on human lymphocytes - Laboratory studies}}, volume = {{21}}, year = {{1989}}, }