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Renal function in a large cohort of metformin treated patients with type 2 diabetes mellitus

Sterner, Gunnar LU ; Elmståhl, Sölve LU and Frid, Anders LU (2012) In British Journal of Diabetes and Vascular Disease 12(5). p.227-231
Abstract

Objectives To survey renal function in a defined population on metformin treatment. Methods All patients in the city of Malmö who collected at least three prescriptions of metformin during two years were identified from a central registry at the National Board of Health and Welfare in Sweden. Estimated glomerular filtration rate (eGFR), from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, of 5,408 patients were compared with a control population (n=2,815) from the same town. All cases of severe lactic acidosis leading to intensive care unit admission were also sought. Results In patients >79 years of age, 38% and 12% of patients had a best recorded eGFR registered below 60 and 45 ml/ min/1.73 m2 respectively.... (More)

Objectives To survey renal function in a defined population on metformin treatment. Methods All patients in the city of Malmö who collected at least three prescriptions of metformin during two years were identified from a central registry at the National Board of Health and Welfare in Sweden. Estimated glomerular filtration rate (eGFR), from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, of 5,408 patients were compared with a control population (n=2,815) from the same town. All cases of severe lactic acidosis leading to intensive care unit admission were also sought. Results In patients >79 years of age, 38% and 12% of patients had a best recorded eGFR registered below 60 and 45 ml/ min/1.73 m2 respectively. In the age group 70-79 years the corresponding figures were 16% and 3% respectively. The eGFR was significantly higher in metformin treated patients than in control subjects in each age group. Three cases of lactic acidosis were recorded during the 2-year period studied. No patient with lactic acidosis was found in the highest age group. Conclusions In spite of reduced and fluctuating GFR in elderly patients, treatment with metformin is feasible. Adjusting the dose of metformin to renal function and adequately informing the patient could enable continuous treatment in moderately reduced GFR.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
CKD-EPI, diabetes mellitus, GFR, glomerular filtration rate, lactic acidosis, metformin
in
British Journal of Diabetes and Vascular Disease
volume
12
issue
5
pages
227 - 231
publisher
SAGE Publications Inc.
external identifiers
  • scopus:84870004836
ISSN
1474-6514
DOI
10.1177/1474651412459544
language
English
LU publication?
yes
id
7b16efe8-7076-47b6-80b6-b9f3a0cda980
date added to LUP
2019-06-19 10:37:54
date last changed
2019-07-29 16:04:17
@article{7b16efe8-7076-47b6-80b6-b9f3a0cda980,
  abstract     = {<p>Objectives To survey renal function in a defined population on metformin treatment. Methods All patients in the city of Malmö who collected at least three prescriptions of metformin during two years were identified from a central registry at the National Board of Health and Welfare in Sweden. Estimated glomerular filtration rate (eGFR), from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, of 5,408 patients were compared with a control population (n=2,815) from the same town. All cases of severe lactic acidosis leading to intensive care unit admission were also sought. Results In patients &gt;79 years of age, 38% and 12% of patients had a best recorded eGFR registered below 60 and 45 ml/ min/1.73 m2 respectively. In the age group 70-79 years the corresponding figures were 16% and 3% respectively. The eGFR was significantly higher in metformin treated patients than in control subjects in each age group. Three cases of lactic acidosis were recorded during the 2-year period studied. No patient with lactic acidosis was found in the highest age group. Conclusions In spite of reduced and fluctuating GFR in elderly patients, treatment with metformin is feasible. Adjusting the dose of metformin to renal function and adequately informing the patient could enable continuous treatment in moderately reduced GFR.</p>},
  author       = {Sterner, Gunnar and Elmståhl, Sölve and Frid, Anders},
  issn         = {1474-6514},
  keyword      = {CKD-EPI,diabetes mellitus,GFR,glomerular filtration rate,lactic acidosis,metformin},
  language     = {eng},
  month        = {09},
  number       = {5},
  pages        = {227--231},
  publisher    = {SAGE Publications Inc.},
  series       = {British Journal of Diabetes and Vascular Disease},
  title        = {Renal function in a large cohort of metformin treated patients with type 2 diabetes mellitus},
  url          = {http://dx.doi.org/10.1177/1474651412459544},
  volume       = {12},
  year         = {2012},
}