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Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.

Kovatcheva-Datchary, Petia ; Nilsson, Anne LU ; Akrami, Rozita ; Lee, Ying Shiuan ; De Vadder, Filipe ; Arora, Tulika ; Hallen, Anna ; Martens, Eric ; Björck, Inger LU and Bäckhed, Fredrik (2015) In Cell Metabolism 22(6). p.971-982
Abstract
The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors... (More)
The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Metabolism
volume
22
issue
6
pages
971 - 982
publisher
Cell Press
external identifiers
  • pmid:26552345
  • wos:000365993100006
  • scopus:84949491459
  • pmid:26552345
ISSN
1550-4131
DOI
10.1016/j.cmet.2015.10.001
project
ANTIDIABETIC FOOD CENTRE
language
English
LU publication?
yes
id
7b1f63a1-6ec8-42cf-93d8-8c0d8b642fea (old id 8236222)
date added to LUP
2016-04-01 10:39:11
date last changed
2022-04-27 23:43:19
@article{7b1f63a1-6ec8-42cf-93d8-8c0d8b642fea,
  abstract     = {{The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.}},
  author       = {{Kovatcheva-Datchary, Petia and Nilsson, Anne and Akrami, Rozita and Lee, Ying Shiuan and De Vadder, Filipe and Arora, Tulika and Hallen, Anna and Martens, Eric and Björck, Inger and Bäckhed, Fredrik}},
  issn         = {{1550-4131}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{971--982}},
  publisher    = {{Cell Press}},
  series       = {{Cell Metabolism}},
  title        = {{Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.}},
  url          = {{http://dx.doi.org/10.1016/j.cmet.2015.10.001}},
  doi          = {{10.1016/j.cmet.2015.10.001}},
  volume       = {{22}},
  year         = {{2015}},
}