Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study
(2024) In European Journal of Nutrition 63(4). p.1329-1338- Abstract
PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.
METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D,... (More)
PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.
METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country.
RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
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- author
- author collaboration
- organization
- publishing date
- 2024-02-27
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Nutrition
- volume
- 63
- issue
- 4
- pages
- 1329 - 1338
- publisher
- Springer
- external identifiers
-
- pmid:38413484
- scopus:85186206593
- ISSN
- 1436-6215
- DOI
- 10.1007/s00394-024-03346-6
- language
- English
- LU publication?
- yes
- additional info
- © 2024. The Author(s).
- id
- 7b60f810-c11c-4517-ac9f-38c5f73e9090
- date added to LUP
- 2024-03-02 09:14:13
- date last changed
- 2025-01-28 22:49:15
@article{7b60f810-c11c-4517-ac9f-38c5f73e9090, abstract = {{<p>PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.</p><p>METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country.</p><p>RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.</p>}}, author = {{Hakola, Leena and Mramba, Lazarus K and Uusitalo, Ulla and Andrén Aronsson, Carin and Hummel, Sandra and Niinistö, Sari and Erlund, Iris and Yang, Jimin and Rewers, Marian J and Akolkar, Beena and McIndoe, Richard A and Rich, Stephen S and Hagopian, William A and Ziegler, Anette and Lernmark, Åke and Toppari, Jorma and Krischer, Jeffrey P and Norris, Jill M and Virtanen, Suvi M}}, issn = {{1436-6215}}, language = {{eng}}, month = {{02}}, number = {{4}}, pages = {{1329--1338}}, publisher = {{Springer}}, series = {{European Journal of Nutrition}}, title = {{Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study}}, url = {{http://dx.doi.org/10.1007/s00394-024-03346-6}}, doi = {{10.1007/s00394-024-03346-6}}, volume = {{63}}, year = {{2024}}, }