The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis - results from the south-Swedish juvenile idiopathic arthritis cohort
(2022) In Pediatric Rheumatology 20(1). p.1-9- Abstract
- Background
Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.
Methods
The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 – 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all... (More) - Background
Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.
Methods
The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 – 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all healthcare contacts in the region, from 1998 to 2019. We used Cox proportional models for the calculation of hazard ratios.
Results
During the study period, 1998 to 2019, 93 (14.5%) of the individuals in the JIA group were diagnosed with depression, and 111 (17.3%) with anxiety. Corresponding numbers among the references was 474 (14.8%) with depression and 557 (17.4%) with anxiety. Hazard ratio for depression was 1.1 (95% CI 0.9 – 1.5) in females and 0.8 (95% CI 0.5 – 1.4) in males, and for anxiety 1.2 (95% CI 0.9 – 1.5) in females and 0.6 (95% CI 0.4 – 1.1) in males. There were no statistically significant hazard ratios when analyzing subgroups of JIA patients with long disease duration or treatment with disease-modifying antirheumatic drugs.
Conclusions
Individuals with JIA do not have any statistically increased risk of being diagnosed with depression or anxiety compared to matched references. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7c6040ef-dcd6-4a2d-bdbc-550c01cb0e7c
- author
- Berthold, Elisabet LU ; Dahlberg, Alma LU ; Jöud, Anna LU ; Tydén, Helena LU ; Månsson, Bengt LU ; Kahn, Fredrik LU and Kahn, Robin LU
- organization
-
- Center of Pediatric Rheumatology (research group)
- WCMM-Wallenberg Centre for Molecular Medicine
- Lund Pediatric Rheumatology Research Group (research group)
- Epidemiology (research group)
- Applied epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Rheumatology
- Neutrophils – new mechanisms and new biomarkers (research group)
- publishing date
- 2022-12-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Rheumatology
- volume
- 20
- issue
- 1
- article number
- 114
- pages
- 1 - 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85143621027
- pmid:36494819
- ISSN
- 1546-0096
- DOI
- 10.1186/s12969-022-00765-9
- language
- English
- LU publication?
- yes
- id
- 7c6040ef-dcd6-4a2d-bdbc-550c01cb0e7c
- date added to LUP
- 2022-12-13 10:03:03
- date last changed
- 2023-04-06 03:04:07
@article{7c6040ef-dcd6-4a2d-bdbc-550c01cb0e7c, abstract = {{Background<br/>Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.<br/><br/>Methods<br/>The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 – 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all healthcare contacts in the region, from 1998 to 2019. We used Cox proportional models for the calculation of hazard ratios.<br/><br/>Results<br/>During the study period, 1998 to 2019, 93 (14.5%) of the individuals in the JIA group were diagnosed with depression, and 111 (17.3%) with anxiety. Corresponding numbers among the references was 474 (14.8%) with depression and 557 (17.4%) with anxiety. Hazard ratio for depression was 1.1 (95% CI 0.9 – 1.5) in females and 0.8 (95% CI 0.5 – 1.4) in males, and for anxiety 1.2 (95% CI 0.9 – 1.5) in females and 0.6 (95% CI 0.4 – 1.1) in males. There were no statistically significant hazard ratios when analyzing subgroups of JIA patients with long disease duration or treatment with disease-modifying antirheumatic drugs.<br/><br/>Conclusions<br/>Individuals with JIA do not have any statistically increased risk of being diagnosed with depression or anxiety compared to matched references.}}, author = {{Berthold, Elisabet and Dahlberg, Alma and Jöud, Anna and Tydén, Helena and Månsson, Bengt and Kahn, Fredrik and Kahn, Robin}}, issn = {{1546-0096}}, language = {{eng}}, month = {{12}}, number = {{1}}, pages = {{1--9}}, publisher = {{BioMed Central (BMC)}}, series = {{Pediatric Rheumatology}}, title = {{The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis - results from the south-Swedish juvenile idiopathic arthritis cohort}}, url = {{http://dx.doi.org/10.1186/s12969-022-00765-9}}, doi = {{10.1186/s12969-022-00765-9}}, volume = {{20}}, year = {{2022}}, }