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The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis - results from the south-Swedish juvenile idiopathic arthritis cohort

Berthold, Elisabet LU ; Dahlberg, Alma LU ; Jöud, Anna LU orcid ; Tydén, Helena LU ; Månsson, Bengt LU orcid ; Kahn, Fredrik LU and Kahn, Robin LU (2022) In Pediatric Rheumatology 20(1). p.1-9
Abstract
Background
Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.

Methods
The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 – 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all... (More)
Background
Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.

Methods
The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 – 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all healthcare contacts in the region, from 1998 to 2019. We used Cox proportional models for the calculation of hazard ratios.

Results
During the study period, 1998 to 2019, 93 (14.5%) of the individuals in the JIA group were diagnosed with depression, and 111 (17.3%) with anxiety. Corresponding numbers among the references was 474 (14.8%) with depression and 557 (17.4%) with anxiety. Hazard ratio for depression was 1.1 (95% CI 0.9 – 1.5) in females and 0.8 (95% CI 0.5 – 1.4) in males, and for anxiety 1.2 (95% CI 0.9 – 1.5) in females and 0.6 (95% CI 0.4 – 1.1) in males. There were no statistically significant hazard ratios when analyzing subgroups of JIA patients with long disease duration or treatment with disease-modifying antirheumatic drugs.

Conclusions
Individuals with JIA do not have any statistically increased risk of being diagnosed with depression or anxiety compared to matched references. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Rheumatology
volume
20
issue
1
article number
114
pages
1 - 9
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85143621027
  • pmid:36494819
ISSN
1546-0096
DOI
10.1186/s12969-022-00765-9
language
English
LU publication?
yes
id
7c6040ef-dcd6-4a2d-bdbc-550c01cb0e7c
date added to LUP
2022-12-13 10:03:03
date last changed
2023-04-06 03:04:07
@article{7c6040ef-dcd6-4a2d-bdbc-550c01cb0e7c,
  abstract     = {{Background<br/>Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.<br/><br/>Methods<br/>The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 – 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all healthcare contacts in the region, from 1998 to 2019. We used Cox proportional models for the calculation of hazard ratios.<br/><br/>Results<br/>During the study period, 1998 to 2019, 93 (14.5%) of the individuals in the JIA group were diagnosed with depression, and 111 (17.3%) with anxiety. Corresponding numbers among the references was 474 (14.8%) with depression and 557 (17.4%) with anxiety. Hazard ratio for depression was 1.1 (95% CI 0.9 – 1.5) in females and 0.8 (95% CI 0.5 – 1.4) in males, and for anxiety 1.2 (95% CI 0.9 – 1.5) in females and 0.6 (95% CI 0.4 – 1.1) in males. There were no statistically significant hazard ratios when analyzing subgroups of JIA patients with long disease duration or treatment with disease-modifying antirheumatic drugs.<br/><br/>Conclusions<br/>Individuals with JIA do not have any statistically increased risk of being diagnosed with depression or anxiety compared to matched references.}},
  author       = {{Berthold, Elisabet and Dahlberg, Alma and Jöud, Anna and Tydén, Helena and Månsson, Bengt and Kahn, Fredrik and Kahn, Robin}},
  issn         = {{1546-0096}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  pages        = {{1--9}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Pediatric Rheumatology}},
  title        = {{The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis - results from the south-Swedish juvenile idiopathic arthritis cohort}},
  url          = {{http://dx.doi.org/10.1186/s12969-022-00765-9}},
  doi          = {{10.1186/s12969-022-00765-9}},
  volume       = {{20}},
  year         = {{2022}},
}