Fetal hemoglobin and alpha(1)-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia
(2011) In American Journal of Obstetrics and Gynecology 204(6).- Abstract
- OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and alpha(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and... (More)
- OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and alpha(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and specificity was obtained using the biomarkers in combination; 69% sensitivity for a 5% screen positive rate and 90% sensitivity for a 23% screen positive rate. CONCLUSION: The study suggests that HbF/Hb ratio in combination with A1M is predictive biomarkers for PE. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1985100
- author
- Dolberg Anderson, Ulrik LU ; Gram, Magnus LU ; Rutardottir, Sigurbjörg LU ; Centlow, Magnus LU ; Kristensen, Karl LU ; Isberg, Per-Erik LU ; Thilaganathan, Baskaran ; Åkerström, Bo LU and Hansson, Stefan LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alpha(1)-microglobulin, first-trimester biomarker, free fetal, hemoglobin, prediction preeclampsia
- in
- American Journal of Obstetrics and Gynecology
- volume
- 204
- issue
- 6
- publisher
- Elsevier
- external identifiers
-
- wos:000291477300031
- pmid:21439542
- scopus:79958082137
- ISSN
- 1097-6868
- DOI
- 10.1016/j.ajog.2011.01.058
- language
- English
- LU publication?
- yes
- id
- 7db11eb0-af68-44c3-9757-9f45eb1e66c4 (old id 1985100)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21439542?dopt=Abstract
- date added to LUP
- 2016-04-01 10:19:50
- date last changed
- 2022-01-25 22:13:01
@article{7db11eb0-af68-44c3-9757-9f45eb1e66c4, abstract = {{OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and alpha(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and specificity was obtained using the biomarkers in combination; 69% sensitivity for a 5% screen positive rate and 90% sensitivity for a 23% screen positive rate. CONCLUSION: The study suggests that HbF/Hb ratio in combination with A1M is predictive biomarkers for PE.}}, author = {{Dolberg Anderson, Ulrik and Gram, Magnus and Rutardottir, Sigurbjörg and Centlow, Magnus and Kristensen, Karl and Isberg, Per-Erik and Thilaganathan, Baskaran and Åkerström, Bo and Hansson, Stefan}}, issn = {{1097-6868}}, keywords = {{alpha(1)-microglobulin; first-trimester biomarker; free fetal; hemoglobin; prediction preeclampsia}}, language = {{eng}}, number = {{6}}, publisher = {{Elsevier}}, series = {{American Journal of Obstetrics and Gynecology}}, title = {{Fetal hemoglobin and alpha(1)-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia}}, url = {{http://dx.doi.org/10.1016/j.ajog.2011.01.058}}, doi = {{10.1016/j.ajog.2011.01.058}}, volume = {{204}}, year = {{2011}}, }