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Reporting guidelines for precision medicine research of clinical relevance : the BePRECISE checklist

Lim, Siew S ; Semnani-Azad, Zhila ; Morieri, Mario L ; Ng, Ashley H ; Ahmad, Abrar LU ; Fitipaldi, Hugo LU ; Boyle, Jacqueline ; Collin, Christian ; Dennis, John M and Langenberg, Claudia , et al. (2024) In Nature Medicine 30(7). p.1874-1881
Abstract

Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reporting, this heterogeneity, combined with the diversity of research tools used in precision medicine studies, makes comparisons across studies and implementation of the findings challenging. Specific recommendations for reporting precision medicine research do not currently exist. The BePRECISE (Better Precision-data Reporting of Evidence from... (More)

Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reporting, this heterogeneity, combined with the diversity of research tools used in precision medicine studies, makes comparisons across studies and implementation of the findings challenging. Specific recommendations for reporting precision medicine research do not currently exist. The BePRECISE (Better Precision-data Reporting of Evidence from Clinical Intervention Studies & Epidemiology) consortium, comprising 23 experts in precision medicine, cardiometabolic diseases, statistics, editorial and lived experience, conducted a scoping review and participated in a modified Delphi and nominal group technique process to develop guidelines for reporting precision medicine research. The BePRECISE checklist comprises 23 items organized into 5 sections that align with typical sections of a scientific publication. A specific section about health equity serves to encourage precision medicine research to be inclusive of individuals and communities that are traditionally under-represented in clinical research and/or underserved by health systems. Adoption of BePRECISE by investigators, reviewers and editors will facilitate and accelerate equitable clinical implementation of precision medicine.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Precision Medicine, Humans, Checklist, Biomedical Research/standards, Research Design/standards, Guidelines as Topic, Clinical Relevance
in
Nature Medicine
volume
30
issue
7
pages
8 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:39030405
  • scopus:85199092982
ISSN
1546-170X
DOI
10.1038/s41591-024-03033-3
language
English
LU publication?
yes
additional info
© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
id
7db41c93-5fb7-4186-b333-674e48ddc7c1
date added to LUP
2024-07-24 12:00:19
date last changed
2024-07-25 12:58:04
@article{7db41c93-5fb7-4186-b333-674e48ddc7c1,
  abstract     = {{<p>Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reporting, this heterogeneity, combined with the diversity of research tools used in precision medicine studies, makes comparisons across studies and implementation of the findings challenging. Specific recommendations for reporting precision medicine research do not currently exist. The BePRECISE (Better Precision-data Reporting of Evidence from Clinical Intervention Studies &amp; Epidemiology) consortium, comprising 23 experts in precision medicine, cardiometabolic diseases, statistics, editorial and lived experience, conducted a scoping review and participated in a modified Delphi and nominal group technique process to develop guidelines for reporting precision medicine research. The BePRECISE checklist comprises 23 items organized into 5 sections that align with typical sections of a scientific publication. A specific section about health equity serves to encourage precision medicine research to be inclusive of individuals and communities that are traditionally under-represented in clinical research and/or underserved by health systems. Adoption of BePRECISE by investigators, reviewers and editors will facilitate and accelerate equitable clinical implementation of precision medicine.</p>}},
  author       = {{Lim, Siew S and Semnani-Azad, Zhila and Morieri, Mario L and Ng, Ashley H and Ahmad, Abrar and Fitipaldi, Hugo and Boyle, Jacqueline and Collin, Christian and Dennis, John M and Langenberg, Claudia and Loos, Ruth J F and Morrison, Melinda and Ramsay, Michele and Sanyal, Arun J and Sattar, Naveed and Hivert, Marie-France and Gomez, Maria F and Merino, Jordi and Tobias, Deirdre K and Trenell, Michael I and Rich, Stephen S and Sargent, Jennifer L and Franks, Paul W}},
  issn         = {{1546-170X}},
  keywords     = {{Precision Medicine; Humans; Checklist; Biomedical Research/standards; Research Design/standards; Guidelines as Topic; Clinical Relevance}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1874--1881}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Medicine}},
  title        = {{Reporting guidelines for precision medicine research of clinical relevance : the BePRECISE checklist}},
  url          = {{http://dx.doi.org/10.1038/s41591-024-03033-3}},
  doi          = {{10.1038/s41591-024-03033-3}},
  volume       = {{30}},
  year         = {{2024}},
}