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Fruits and vegetables and renal cell carcinoma: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Weikert, S ; Boeing, H ; Pischon, T ; Olsen, A ; Tjonneland, A ; Overvad, K ; Becker, N ; Linseisen, J ; Lahmann, PH and Arvaniti, A , et al. (2006) In International Journal of Cancer 118(12). p.3133-3139
Abstract
We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and... (More)
We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation. (Less)
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publication status
published
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keywords
incidence, food, cohort study, epidemiology, kidney cancer
in
International Journal of Cancer
volume
118
issue
12
pages
3133 - 3139
publisher
John Wiley & Sons
external identifiers
  • wos:000237331600029
  • pmid:16425278
  • scopus:33646410103
  • pmid:16425278
ISSN
0020-7136
DOI
10.1002/ijc.21765
language
English
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yes
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7dbe0394-d287-4402-85b0-82643f913f88 (old id 409528)
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2016-04-01 11:55:19
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2019-05-14 01:57:26
@article{7dbe0394-d287-4402-85b0-82643f913f88,
  abstract     = {We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation.},
  author       = {Weikert, S and Boeing, H and Pischon, T and Olsen, A and Tjonneland, A and Overvad, K and Becker, N and Linseisen, J and Lahmann, PH and Arvaniti, A and Kassapa, C and Trichoupoulou, A and Sieri, S and Palli, D and Tumino, R and Vineis, P and Panico, S and van Gils, CH and Peeters, PHM and Bueno-De-Mesquita, HB and Buchner, FL and Berglund, Göran and Wirfält, Elisabet and Ljungberg, B and Hallmans, G and Pera, G and Dorronsoro, M and Barricarte Gurrea, A and Navarro, C and Martinez, C and Quorós, J R and Allen, N and Roddam, A and Bingham, S and Jenab, M and Slimani, N and Norat, T and Riboli, E},
  issn         = {0020-7136},
  language     = {eng},
  number       = {12},
  pages        = {3133--3139},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fruits and vegetables and renal cell carcinoma: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.21765},
  doi          = {10.1002/ijc.21765},
  volume       = {118},
  year         = {2006},
}