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Effect of food intake on 92 biomarkers for cardiovascular disease

Dencker, Magnus LU ; Gårdinger, Ylva LU ; Björgell, Ola LU and Hlebowicz, Joanna LU (2017) In PLoS ONE 12(6).
Abstract

Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD). Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit. Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or... (More)

Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD). Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit. Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake. Conclusions: This study shows that food intake affects several different CVD biomarkers, but the effect is predominantly modest. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Further studies are warranted in older healthy subjects and in patients with various cardiac diseases to determine whether the findings are reproducible.

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publication status
published
subject
in
PLoS ONE
volume
12
issue
6
publisher
Public Library of Science
external identifiers
  • scopus:85020226298
  • wos:000402875700020
ISSN
1932-6203
DOI
10.1371/journal.pone.0178656
language
English
LU publication?
yes
id
7f4ce58f-3ac7-42e5-95b5-889061c14798
date added to LUP
2017-07-28 12:09:44
date last changed
2017-09-18 11:40:12
@article{7f4ce58f-3ac7-42e5-95b5-889061c14798,
  abstract     = {<p>Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD). Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit. Results: The levels for eight biomarkers decreased significantly (P&lt;0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake. Conclusions: This study shows that food intake affects several different CVD biomarkers, but the effect is predominantly modest. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Further studies are warranted in older healthy subjects and in patients with various cardiac diseases to determine whether the findings are reproducible.</p>},
  articleno    = {e0178656},
  author       = {Dencker, Magnus and Gårdinger, Ylva and Björgell, Ola and Hlebowicz, Joanna},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Effect of food intake on 92 biomarkers for cardiovascular disease},
  url          = {http://dx.doi.org/10.1371/journal.pone.0178656},
  volume       = {12},
  year         = {2017},
}