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Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?

Jirenhed, Dan-Anders LU and Hesslow, Germund LU (2015) In Cerebellum
Abstract
Several lines of evidence show that classical or Pavlovian conditioning of blink responses depends on the cerebellum. Recordings from cerebellar Purkinje cells that control the eyelid and the conditioned blink show that during training with a conditioning protocol, a Purkinje cell develops a pause response to the conditional stimulus. This conditioned cellular response has many of the properties that characterise the overt blink. The present paper argues that the learned Purkinje cell pause response is the memory trace and main driver of the overt conditioned blink and that it explains many well-known behavioural phenomena.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Purkinje cells . Classical conditioning . Cerebellum . Simple spikes . Timing
in
Cerebellum
publisher
Informa Healthcare
external identifiers
  • PMID:26400585
  • Scopus:84944699334
ISSN
1473-4230
DOI
10.1007/s12311-015-0722-4
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
7fb6d712-7934-46ca-abef-58774dca737a (old id 8035096)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26400585?dopt=Abstract
date added to LUP
2015-10-03 16:11:08
date last changed
2017-01-01 07:39:53
@article{7fb6d712-7934-46ca-abef-58774dca737a,
  abstract     = {Several lines of evidence show that classical or Pavlovian conditioning of blink responses depends on the cerebellum. Recordings from cerebellar Purkinje cells that control the eyelid and the conditioned blink show that during training with a conditioning protocol, a Purkinje cell develops a pause response to the conditional stimulus. This conditioned cellular response has many of the properties that characterise the overt blink. The present paper argues that the learned Purkinje cell pause response is the memory trace and main driver of the overt conditioned blink and that it explains many well-known behavioural phenomena.},
  author       = {Jirenhed, Dan-Anders and Hesslow, Germund},
  issn         = {1473-4230},
  keyword      = {Purkinje cells . Classical conditioning . Cerebellum . Simple spikes . Timing},
  language     = {eng},
  month        = {09},
  publisher    = {Informa Healthcare},
  series       = {Cerebellum},
  title        = {Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?},
  url          = {http://dx.doi.org/10.1007/s12311-015-0722-4},
  year         = {2015},
}