Treatment of Parkinson's disease using cell transplantation.
(2015) In Philosophical Transactions of the Royal Society B: Biological Sciences 370(1680).- Abstract
- The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to produce dopaminergic neurons for transplantation. Importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready... (More)
- The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to produce dopaminergic neurons for transplantation. Importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready for application in patients. Also, human induced pluripotent stem cell-derived dopaminergic neurons are being considered for clinical translation. Available data justify moving forward in a responsible way with these dopaminergic neurons, which should be tested, using optimal patient selection, cell preparation and transplantation procedures, in controlled clinical studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8034580
- author
- Lindvall, Olle LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Philosophical Transactions of the Royal Society B: Biological Sciences
- volume
- 370
- issue
- 1680
- article number
- 20140370
- publisher
- Royal Society Publishing
- external identifiers
-
- pmid:26416681
- wos:000362719500007
- scopus:84942912716
- pmid:26416681
- ISSN
- 1471-2970
- DOI
- 10.1098/rstb.2014.0370
- language
- English
- LU publication?
- yes
- id
- c409ea0f-374d-44a5-a6e5-008572252e83 (old id 8034580)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26416681?dopt=Abstract
- date added to LUP
- 2016-04-01 10:28:09
- date last changed
- 2022-03-27 08:39:22
@article{c409ea0f-374d-44a5-a6e5-008572252e83,
abstract = {{The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to produce dopaminergic neurons for transplantation. Importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready for application in patients. Also, human induced pluripotent stem cell-derived dopaminergic neurons are being considered for clinical translation. Available data justify moving forward in a responsible way with these dopaminergic neurons, which should be tested, using optimal patient selection, cell preparation and transplantation procedures, in controlled clinical studies.}},
author = {{Lindvall, Olle}},
issn = {{1471-2970}},
language = {{eng}},
number = {{1680}},
publisher = {{Royal Society Publishing}},
series = {{Philosophical Transactions of the Royal Society B: Biological Sciences}},
title = {{Treatment of Parkinson's disease using cell transplantation.}},
url = {{http://dx.doi.org/10.1098/rstb.2014.0370}},
doi = {{10.1098/rstb.2014.0370}},
volume = {{370}},
year = {{2015}},
}