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Treatment of Parkinson's disease using cell transplantation.

Lindvall, Olle LU (2015) In Royal Society of London. Philosophical Transactions B. Biological Sciences 370(1680).
Abstract
The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to produce dopaminergic neurons for transplantation. Importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready... (More)
The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to produce dopaminergic neurons for transplantation. Importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready for application in patients. Also, human induced pluripotent stem cell-derived dopaminergic neurons are being considered for clinical translation. Available data justify moving forward in a responsible way with these dopaminergic neurons, which should be tested, using optimal patient selection, cell preparation and transplantation procedures, in controlled clinical studies. (Less)
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Contribution to journal
publication status
published
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in
Royal Society of London. Philosophical Transactions B. Biological Sciences
volume
370
issue
1680
publisher
Royal Society
external identifiers
  • pmid:26416681
  • wos:000362719500007
  • scopus:84942912716
ISSN
1471-2970
DOI
10.1098/rstb.2014.0370
language
English
LU publication?
yes
id
c409ea0f-374d-44a5-a6e5-008572252e83 (old id 8034580)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26416681?dopt=Abstract
date added to LUP
2015-10-03 13:01:22
date last changed
2017-11-12 03:08:16
@article{c409ea0f-374d-44a5-a6e5-008572252e83,
  abstract     = {The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to produce dopaminergic neurons for transplantation. Importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready for application in patients. Also, human induced pluripotent stem cell-derived dopaminergic neurons are being considered for clinical translation. Available data justify moving forward in a responsible way with these dopaminergic neurons, which should be tested, using optimal patient selection, cell preparation and transplantation procedures, in controlled clinical studies.},
  articleno    = {20140370},
  author       = {Lindvall, Olle},
  issn         = {1471-2970},
  language     = {eng},
  number       = {1680},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Philosophical Transactions B. Biological Sciences},
  title        = {Treatment of Parkinson's disease using cell transplantation.},
  url          = {http://dx.doi.org/10.1098/rstb.2014.0370},
  volume       = {370},
  year         = {2015},
}