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ESTIMATES OF BREAST CANCER GROWTH RATE FROM MAMMOGRAMS AND ITS RELATION TO TUMOUR CHARACTERISTICS.

Förnvik, Daniel LU orcid ; Lång, Kristina LU ; Andersson, Ingvar LU ; Dustler, Magnus LU orcid ; Borgquist, Signe LU and Timberg, Pontus LU (2016) In Radiation Protection Dosimetry 169. p.151-157
Abstract
This study aimed to investigate the growth rate of 31 consecutive invasive breast cancers based on volume measures on at least two serial mammograms and its relation to histopathological findings. The average tumour volume-doubling time in all invasive breast cancer subtypes was 282 d (range 46-749 d). Grade III breast cancers had a significantly shorter average tumour volume-doubling time of 105 d (range 46-157 d) compared with Grade I and II tumours (average of 296 d, range 147-531 d and average of 353 d, range 139-749 d, respectively) (p = 0.002). Multiple linear regression identified that tumour volume-doubling time was positively associated with patient age, histological grade and progesterone receptor expression and inversely... (More)
This study aimed to investigate the growth rate of 31 consecutive invasive breast cancers based on volume measures on at least two serial mammograms and its relation to histopathological findings. The average tumour volume-doubling time in all invasive breast cancer subtypes was 282 d (range 46-749 d). Grade III breast cancers had a significantly shorter average tumour volume-doubling time of 105 d (range 46-157 d) compared with Grade I and II tumours (average of 296 d, range 147-531 d and average of 353 d, range 139-749 d, respectively) (p = 0.002). Multiple linear regression identified that tumour volume-doubling time was positively associated with patient age, histological grade and progesterone receptor expression and inversely associated with axillary lymph node involvement, human epidermal growth factor receptor 2 and Ki-67 expression (p < 0.001). In conclusion, tumour volume-doubling time as estimated on serial mammography may provide important prognostic information relevant for clinical decision-making. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
169
pages
151 - 157
publisher
Oxford University Press
external identifiers
  • pmid:26410768
  • pmid:26410768
  • scopus:84979008619
  • wos:000383492100023
ISSN
1742-3406
DOI
10.1093/rpd/ncv417
language
English
LU publication?
yes
id
5a30e47c-40d2-4cb7-83f7-38ed7615a40d (old id 8034840)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26410768?dopt=Abstract
date added to LUP
2016-04-04 09:40:03
date last changed
2025-01-06 11:33:33
@article{5a30e47c-40d2-4cb7-83f7-38ed7615a40d,
  abstract     = {{This study aimed to investigate the growth rate of 31 consecutive invasive breast cancers based on volume measures on at least two serial mammograms and its relation to histopathological findings. The average tumour volume-doubling time in all invasive breast cancer subtypes was 282 d (range 46-749 d). Grade III breast cancers had a significantly shorter average tumour volume-doubling time of 105 d (range 46-157 d) compared with Grade I and II tumours (average of 296 d, range 147-531 d and average of 353 d, range 139-749 d, respectively) (p = 0.002). Multiple linear regression identified that tumour volume-doubling time was positively associated with patient age, histological grade and progesterone receptor expression and inversely associated with axillary lymph node involvement, human epidermal growth factor receptor 2 and Ki-67 expression (p &lt; 0.001). In conclusion, tumour volume-doubling time as estimated on serial mammography may provide important prognostic information relevant for clinical decision-making.}},
  author       = {{Förnvik, Daniel and Lång, Kristina and Andersson, Ingvar and Dustler, Magnus and Borgquist, Signe and Timberg, Pontus}},
  issn         = {{1742-3406}},
  language     = {{eng}},
  pages        = {{151--157}},
  publisher    = {{Oxford University Press}},
  series       = {{Radiation Protection Dosimetry}},
  title        = {{ESTIMATES OF BREAST CANCER GROWTH RATE FROM MAMMOGRAMS AND ITS RELATION TO TUMOUR CHARACTERISTICS.}},
  url          = {{https://lup.lub.lu.se/search/files/9055095/Oxford_Fornvik_et_al.pdf}},
  doi          = {{10.1093/rpd/ncv417}},
  volume       = {{169}},
  year         = {{2016}},
}