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Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice.

Bay-Richter, Cecilie ; Janelidze, Shorena LU ; Sauro, Analise ; Bucala, Richard ; Lipton, Jack ; Deierborg, Tomas LU orcid and Brundin, Lena (2015) In Journal of Neuroinflammation 12(1).
Abstract
Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocorticoids. Increased plasma levels of MIF are associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and depressive symptoms in patients. In contrast, MIF knockout (KO) mice have been found to exhibit increased depressive-like behaviour. The exact role for MIF in depression is therefore still controversial. To further understand the... (More)
Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocorticoids. Increased plasma levels of MIF are associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and depressive symptoms in patients. In contrast, MIF knockout (KO) mice have been found to exhibit increased depressive-like behaviour. The exact role for MIF in depression is therefore still controversial. To further understand the role of MIF in depression, we studied depressive-like behaviour in congenic male and female MIF KO mice and wild-type (WT) littermates and the associated neurobiological mechanisms underlying the behavioural outcome. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroinflammation
volume
12
issue
1
article number
163
publisher
BioMed Central (BMC)
external identifiers
  • pmid:26338025
  • wos:000360786300009
  • scopus:84940732967
  • pmid:26338025
ISSN
1742-2094
DOI
10.1186/s12974-015-0387-4
language
English
LU publication?
yes
id
a8fa48b0-05e2-460a-ae42-804fa029b239 (old id 8043243)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26338025?dopt=Abstract
date added to LUP
2016-04-01 12:59:40
date last changed
2025-04-04 13:54:47
@article{a8fa48b0-05e2-460a-ae42-804fa029b239,
  abstract     = {{Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocorticoids. Increased plasma levels of MIF are associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and depressive symptoms in patients. In contrast, MIF knockout (KO) mice have been found to exhibit increased depressive-like behaviour. The exact role for MIF in depression is therefore still controversial. To further understand the role of MIF in depression, we studied depressive-like behaviour in congenic male and female MIF KO mice and wild-type (WT) littermates and the associated neurobiological mechanisms underlying the behavioural outcome.}},
  author       = {{Bay-Richter, Cecilie and Janelidze, Shorena and Sauro, Analise and Bucala, Richard and Lipton, Jack and Deierborg, Tomas and Brundin, Lena}},
  issn         = {{1742-2094}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Neuroinflammation}},
  title        = {{Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice.}},
  url          = {{https://lup.lub.lu.se/search/files/3095268/8852345.pdf}},
  doi          = {{10.1186/s12974-015-0387-4}},
  volume       = {{12}},
  year         = {{2015}},
}