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Impaired CXCR1-dependent oxidative defence in active tuberculosis patients.

Alaridah, Nader LU ; Winqvist, Niclas LU ; Håkansson, Gisela LU ; Tenland, Erik LU ; Rönnholm, Anna LU ; Sturegård, Erik LU ; Björkman, Per LU and Godaly, Gabriela LU (2015) In Tuberculosis 95(6). p.744-750
Abstract
Much of the pronounced host inflammatory response that occurs in tuberculosis (TB) is related to failed immunity against the invading pathogen. The G-protein coupled receptors CXCR1 and CXCR2 are implicated in important signal transduction pathways in lung inflammatory responses. We investigated the expression and function of these receptors in a simple whole blood model from 24 patients with pulmonary TB and in subjects with latent TB infection (LTBI). Healthy controls were recruited from close contacts to the pulmonary index patients. We found that pulmonary TB patients had significantly increased CXCR1 expression on blood cells compared to LTBI subjects and controls (p < 0.001). In contrast, LTBI subjects had a significant increase... (More)
Much of the pronounced host inflammatory response that occurs in tuberculosis (TB) is related to failed immunity against the invading pathogen. The G-protein coupled receptors CXCR1 and CXCR2 are implicated in important signal transduction pathways in lung inflammatory responses. We investigated the expression and function of these receptors in a simple whole blood model from 24 patients with pulmonary TB and in subjects with latent TB infection (LTBI). Healthy controls were recruited from close contacts to the pulmonary index patients. We found that pulmonary TB patients had significantly increased CXCR1 expression on blood cells compared to LTBI subjects and controls (p < 0.001). In contrast, LTBI subjects had a significant increase in CXCR2 expression compared to pulmonary TB patients (p < 0.001) and controls (p < 0.01). Leukocyte function, measured as oxidative capacity, was decreased in pulmonary TB patients compared to LTBI and controls (p < 0.001) and correlated with the increased CXCR1 expression. Leukocyte recruitment, measured as the expression of microRNA-223 was increased in pulmonary TB patients compared to LTBI (p < 0.05). We found that variations in receptor expression are linked to disease progression and affect the immune response against Mycobacterium tuberculosis (Mtb). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Tuberculosis
volume
95
issue
6
pages
744 - 750
publisher
Elsevier
external identifiers
  • pmid:26316141
  • wos:000365626300015
  • scopus:84948711892
ISSN
1873-281X
DOI
10.1016/j.tube.2015.07.008
language
English
LU publication?
yes
id
24ee6eb7-bc7c-4a1e-8622-07eae8153beb (old id 8043820)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26316141?dopt=Abstract
date added to LUP
2015-10-07 21:52:39
date last changed
2017-05-21 03:04:51
@article{24ee6eb7-bc7c-4a1e-8622-07eae8153beb,
  abstract     = {Much of the pronounced host inflammatory response that occurs in tuberculosis (TB) is related to failed immunity against the invading pathogen. The G-protein coupled receptors CXCR1 and CXCR2 are implicated in important signal transduction pathways in lung inflammatory responses. We investigated the expression and function of these receptors in a simple whole blood model from 24 patients with pulmonary TB and in subjects with latent TB infection (LTBI). Healthy controls were recruited from close contacts to the pulmonary index patients. We found that pulmonary TB patients had significantly increased CXCR1 expression on blood cells compared to LTBI subjects and controls (p &lt; 0.001). In contrast, LTBI subjects had a significant increase in CXCR2 expression compared to pulmonary TB patients (p &lt; 0.001) and controls (p &lt; 0.01). Leukocyte function, measured as oxidative capacity, was decreased in pulmonary TB patients compared to LTBI and controls (p &lt; 0.001) and correlated with the increased CXCR1 expression. Leukocyte recruitment, measured as the expression of microRNA-223 was increased in pulmonary TB patients compared to LTBI (p &lt; 0.05). We found that variations in receptor expression are linked to disease progression and affect the immune response against Mycobacterium tuberculosis (Mtb).},
  author       = {Alaridah, Nader and Winqvist, Niclas and Håkansson, Gisela and Tenland, Erik and Rönnholm, Anna and Sturegård, Erik and Björkman, Per and Godaly, Gabriela},
  issn         = {1873-281X},
  language     = {eng},
  number       = {6},
  pages        = {744--750},
  publisher    = {Elsevier},
  series       = {Tuberculosis},
  title        = {Impaired CXCR1-dependent oxidative defence in active tuberculosis patients.},
  url          = {http://dx.doi.org/10.1016/j.tube.2015.07.008},
  volume       = {95},
  year         = {2015},
}