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A new tomographic technique for absolute measurements of white and gray matter blood flow

Risberg, Jarl LU ; Börjesson, Siv LU and Ljunggren, Kaj LU (2003) The Thirty-First Annual International Neuropsychological Society Conference In Journal of the International Neuropsychological Society 9. p.323-323
Abstract
The integrity of the white matter is as important as that of the gray matter and white matter pathology has commonly been reported in elderly subjects and in patients with organic dementia. The aim of the present study is to develop and evaluate an improved method for reliable tomographic measurements of absolute white and gray matter blood flow. The new tomographic method (modified Xe-SPECT) is based on an extension of the period of 133Xe inhalation from one to eight minutes followed by 22 instead of four minutes of breathing of ambient air. This gives a markedly enhanced signal from the white matter and better basis for correct quantification pf the blood flow. The arrival and clearance of the tracer are recorded by a three head gamma... (More)
The integrity of the white matter is as important as that of the gray matter and white matter pathology has commonly been reported in elderly subjects and in patients with organic dementia. The aim of the present study is to develop and evaluate an improved method for reliable tomographic measurements of absolute white and gray matter blood flow. The new tomographic method (modified Xe-SPECT) is based on an extension of the period of 133Xe inhalation from one to eight minutes followed by 22 instead of four minutes of breathing of ambient air. This gives a markedly enhanced signal from the white matter and better basis for correct quantification pf the blood flow. The arrival and clearance of the tracer are recorded by a three head gamma camera system that provides flow maps with a spatial resolution of about one cm. The new method has been evaluated in healthy younger and older (around 70 years) subjects as well as in a group of elderly patients with organic dementia. Our preliminary findings indicate that new and clinically valuable information is obtained by the improved Xe-SPECT method (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the International Neuropsychological Society
volume
9
pages
323 - 323
publisher
Cambridge University Press
conference name
The Thirty-First Annual International Neuropsychological Society Conference
ISSN
1355-6177
DOI
10.1017/S1355617703920017
language
English
LU publication?
yes
id
a31c098d-ca75-417b-9c3b-dc80d619cd39 (old id 806310)
date added to LUP
2008-01-31 13:14:48
date last changed
2016-06-08 12:23:12
@misc{a31c098d-ca75-417b-9c3b-dc80d619cd39,
  abstract     = {The integrity of the white matter is as important as that of the gray matter and white matter pathology has commonly been reported in elderly subjects and in patients with organic dementia. The aim of the present study is to develop and evaluate an improved method for reliable tomographic measurements of absolute white and gray matter blood flow. The new tomographic method (modified Xe-SPECT) is based on an extension of the period of 133Xe inhalation from one to eight minutes followed by 22 instead of four minutes of breathing of ambient air. This gives a markedly enhanced signal from the white matter and better basis for correct quantification pf the blood flow. The arrival and clearance of the tracer are recorded by a three head gamma camera system that provides flow maps with a spatial resolution of about one cm. The new method has been evaluated in healthy younger and older (around 70 years) subjects as well as in a group of elderly patients with organic dementia. Our preliminary findings indicate that new and clinically valuable information is obtained by the improved Xe-SPECT method},
  author       = {Risberg, Jarl and Börjesson, Siv and Ljunggren, Kaj},
  issn         = {1355-6177},
  language     = {eng},
  note         = {Conference Abstract},
  pages        = {323--323},
  publisher    = {Cambridge University Press},
  series       = {Journal of the International Neuropsychological Society},
  title        = {A new tomographic technique for absolute measurements of white and gray matter blood flow},
  url          = {http://dx.doi.org/10.1017/S1355617703920017},
  volume       = {9},
  year         = {2003},
}