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Prenatal phthalate exposure was associated with croup in Swedish infants

Shu, Huan; Wikstrom, Sverre; Jönsson, Bo A.G. LU ; Lindh, Christian H. LU ; Svensson, Åke LU ; Nånberg, Eewa and Bornehag, Carl Gustaf (2018) In Acta Paediatrica, International Journal of Paediatrics 107(6). p.1011-1019
Abstract

Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP)... (More)

Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life. Conclusion: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Croup, Exposure, Phthalate, Pregnant, SELMA study
in
Acta Paediatrica, International Journal of Paediatrics
volume
107
issue
6
pages
9 pages
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85046728033
ISSN
0803-5253
DOI
10.1111/apa.14245
language
English
LU publication?
yes
id
80c80270-180f-467a-b2a4-56bd16018ff1
date added to LUP
2018-05-23 12:37:17
date last changed
2019-02-20 11:17:44
@article{80c80270-180f-467a-b2a4-56bd16018ff1,
  abstract     = {<p>Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life. Conclusion: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.</p>},
  author       = {Shu, Huan and Wikstrom, Sverre and Jönsson, Bo A.G. and Lindh, Christian H. and Svensson, Åke and Nånberg, Eewa and Bornehag, Carl Gustaf},
  issn         = {0803-5253},
  keyword      = {Croup,Exposure,Phthalate,Pregnant,SELMA study},
  language     = {eng},
  month        = {06},
  number       = {6},
  pages        = {1011--1019},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Prenatal phthalate exposure was associated with croup in Swedish infants},
  url          = {http://dx.doi.org/10.1111/apa.14245},
  volume       = {107},
  year         = {2018},
}