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Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas platform

Larsson, Sara Marie LU ; Hillarp, Andreas LU ; Karlsland Åkeson, Pia LU ; Hellström-Westas, Lena LU ; Domellöf, Magnus ; Askelöf, Ulrica ; Götherström, Cecilia and Andersson, Ola LU orcid (2021) In International Journal of Laboratory Hematology 43(3). p.378-386
Abstract

INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.

METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations >1 mg/L and sTfR was tested by Kendall correlation.

RESULTS: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth,... (More)

INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.

METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations >1 mg/L and sTfR was tested by Kendall correlation.

RESULTS: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth, 2.9-8.4 mg/L at 48-96 hours, 2.6-5.7 mg/L at 4 months and 3.0-6.3 mg/L at 12 months. No differences between sexes were observed except for at 4 months. sTfR did not covariate with CRP concentrations >1 mg/L except in 48-96 hours samples.

CONCLUSION: This study reports reference intervals for sTfR from birth to 12 months of age in a large group of infants in a low-risk area for iron deficiency. sTfR might add value to infant iron status diagnostics since no covariation with CRP was found at birth, at 4 months or at 12 months.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Laboratory Hematology
volume
43
issue
3
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85096717712
  • pmid:33217104
ISSN
1751-5521
DOI
10.1111/ijlh.13391
language
English
LU publication?
yes
additional info
© 2020 The Authors. International Journal of Laboratory Hematology published by John Wiley & Sons Ltd.
id
8101135b-8c05-4eaa-a30e-42b991b5874f
date added to LUP
2020-11-30 10:48:30
date last changed
2024-06-27 03:10:02
@article{8101135b-8c05-4eaa-a30e-42b991b5874f,
  abstract     = {{<p>INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.</p><p>METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations &gt;1 mg/L and sTfR was tested by Kendall correlation.</p><p>RESULTS: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth, 2.9-8.4 mg/L at 48-96 hours, 2.6-5.7 mg/L at 4 months and 3.0-6.3 mg/L at 12 months. No differences between sexes were observed except for at 4 months. sTfR did not covariate with CRP concentrations &gt;1 mg/L except in 48-96 hours samples.</p><p>CONCLUSION: This study reports reference intervals for sTfR from birth to 12 months of age in a large group of infants in a low-risk area for iron deficiency. sTfR might add value to infant iron status diagnostics since no covariation with CRP was found at birth, at 4 months or at 12 months.</p>}},
  author       = {{Larsson, Sara Marie and Hillarp, Andreas and Karlsland Åkeson, Pia and Hellström-Westas, Lena and Domellöf, Magnus and Askelöf, Ulrica and Götherström, Cecilia and Andersson, Ola}},
  issn         = {{1751-5521}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{3}},
  pages        = {{378--386}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{International Journal of Laboratory Hematology}},
  title        = {{Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas platform}},
  url          = {{http://dx.doi.org/10.1111/ijlh.13391}},
  doi          = {{10.1111/ijlh.13391}},
  volume       = {{43}},
  year         = {{2021}},
}