Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas platform
(2021) In International Journal of Laboratory Hematology 43(3). p.378-386- Abstract
INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.
METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations >1 mg/L and sTfR was tested by Kendall correlation.
RESULTS: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth,... (More)
INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.
METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations >1 mg/L and sTfR was tested by Kendall correlation.
RESULTS: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth, 2.9-8.4 mg/L at 48-96 hours, 2.6-5.7 mg/L at 4 months and 3.0-6.3 mg/L at 12 months. No differences between sexes were observed except for at 4 months. sTfR did not covariate with CRP concentrations >1 mg/L except in 48-96 hours samples.
CONCLUSION: This study reports reference intervals for sTfR from birth to 12 months of age in a large group of infants in a low-risk area for iron deficiency. sTfR might add value to infant iron status diagnostics since no covariation with CRP was found at birth, at 4 months or at 12 months.
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- author
- Larsson, Sara Marie
LU
; Hillarp, Andreas
LU
; Karlsland Åkeson, Pia
LU
; Hellström-Westas, Lena
LU
; Domellöf, Magnus
; Askelöf, Ulrica
; Götherström, Cecilia
and Andersson, Ola
LU
- organization
- publishing date
- 2021-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Laboratory Hematology
- volume
- 43
- issue
- 3
- pages
- 9 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85096717712
- pmid:33217104
- ISSN
- 1751-5521
- DOI
- 10.1111/ijlh.13391
- language
- English
- LU publication?
- yes
- additional info
- © 2020 The Authors. International Journal of Laboratory Hematology published by John Wiley & Sons Ltd.
- id
- 8101135b-8c05-4eaa-a30e-42b991b5874f
- date added to LUP
- 2020-11-30 10:48:30
- date last changed
- 2024-06-27 03:10:02
@article{8101135b-8c05-4eaa-a30e-42b991b5874f, abstract = {{<p>INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.</p><p>METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations >1 mg/L and sTfR was tested by Kendall correlation.</p><p>RESULTS: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth, 2.9-8.4 mg/L at 48-96 hours, 2.6-5.7 mg/L at 4 months and 3.0-6.3 mg/L at 12 months. No differences between sexes were observed except for at 4 months. sTfR did not covariate with CRP concentrations >1 mg/L except in 48-96 hours samples.</p><p>CONCLUSION: This study reports reference intervals for sTfR from birth to 12 months of age in a large group of infants in a low-risk area for iron deficiency. sTfR might add value to infant iron status diagnostics since no covariation with CRP was found at birth, at 4 months or at 12 months.</p>}}, author = {{Larsson, Sara Marie and Hillarp, Andreas and Karlsland Åkeson, Pia and Hellström-Westas, Lena and Domellöf, Magnus and Askelöf, Ulrica and Götherström, Cecilia and Andersson, Ola}}, issn = {{1751-5521}}, language = {{eng}}, month = {{06}}, number = {{3}}, pages = {{378--386}}, publisher = {{Wiley-Blackwell}}, series = {{International Journal of Laboratory Hematology}}, title = {{Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas platform}}, url = {{http://dx.doi.org/10.1111/ijlh.13391}}, doi = {{10.1111/ijlh.13391}}, volume = {{43}}, year = {{2021}}, }