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EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases

Lind, Lars ; Elmståhl, Sölve LU ; Bergman, Ebba ; Englund, Martin LU ; Lindberg, Eva ; Michaelsson, Karl ; Nilsson, Peter LU and Sundstrom, Johan (2013) In European Journal of Epidemiology 28(2). p.189-197
Abstract
The most common diseases affecting middle-aged and elderly subjects in industrialized countries are multigenetic and lifestyle related. Several attempts have been made to study interactions between genes and lifestyle factors, but most such studies lack the power to examine interactions between several genes and several lifestyle components. The primary objective of the EpiHealth cohort study is to provide a resource to study interactions between several genotypes and lifestyle factors in a large cohort (the aim is 300,000 individuals) derived from the Swedish population in the age range of 45-75 years regarding development of common degenerative disorders, such as cardiovascular diseases, cancer, dementia, joint pain, obstructive lung... (More)
The most common diseases affecting middle-aged and elderly subjects in industrialized countries are multigenetic and lifestyle related. Several attempts have been made to study interactions between genes and lifestyle factors, but most such studies lack the power to examine interactions between several genes and several lifestyle components. The primary objective of the EpiHealth cohort study is to provide a resource to study interactions between several genotypes and lifestyle factors in a large cohort (the aim is 300,000 individuals) derived from the Swedish population in the age range of 45-75 years regarding development of common degenerative disorders, such as cardiovascular diseases, cancer, dementia, joint pain, obstructive lung disease, depression, and osteoporotic fractures. The study consists of three parts. First, a collection of data on lifestyle factors by self-assessment using an internet-based questionnaire. Second, a visit to a test center where blood samples are collected and physiological parameters recorded. Third, the sample is followed for occurrence of outcomes using nationwide medical registers. This overview presents the study design and some baseline characteristics from the first year of data collection in the EpiHealth study. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epidemiology, Lifestyle, Gene, Prospective, Cohort study
in
European Journal of Epidemiology
volume
28
issue
2
pages
189 - 197
publisher
Springer
external identifiers
  • wos:000316638900009
  • scopus:84879502324
ISSN
1573-7284
DOI
10.1007/s10654-013-9787-x
language
English
LU publication?
yes
id
810bd522-d278-4220-822b-bb5ccb0135e6 (old id 3765217)
date added to LUP
2016-04-01 10:28:51
date last changed
2019-10-29 01:21:50
@article{810bd522-d278-4220-822b-bb5ccb0135e6,
  abstract     = {The most common diseases affecting middle-aged and elderly subjects in industrialized countries are multigenetic and lifestyle related. Several attempts have been made to study interactions between genes and lifestyle factors, but most such studies lack the power to examine interactions between several genes and several lifestyle components. The primary objective of the EpiHealth cohort study is to provide a resource to study interactions between several genotypes and lifestyle factors in a large cohort (the aim is 300,000 individuals) derived from the Swedish population in the age range of 45-75 years regarding development of common degenerative disorders, such as cardiovascular diseases, cancer, dementia, joint pain, obstructive lung disease, depression, and osteoporotic fractures. The study consists of three parts. First, a collection of data on lifestyle factors by self-assessment using an internet-based questionnaire. Second, a visit to a test center where blood samples are collected and physiological parameters recorded. Third, the sample is followed for occurrence of outcomes using nationwide medical registers. This overview presents the study design and some baseline characteristics from the first year of data collection in the EpiHealth study.},
  author       = {Lind, Lars and Elmståhl, Sölve and Bergman, Ebba and Englund, Martin and Lindberg, Eva and Michaelsson, Karl and Nilsson, Peter and Sundstrom, Johan},
  issn         = {1573-7284},
  language     = {eng},
  number       = {2},
  pages        = {189--197},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases},
  url          = {http://dx.doi.org/10.1007/s10654-013-9787-x},
  doi          = {10.1007/s10654-013-9787-x},
  volume       = {28},
  year         = {2013},
}