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Familial risks for asthma among twins and other siblings based on hospitalizations in Sweden

Hemminki, K LU ; Li, X LU ; Sundquist, K LU and Sundquist, J LU (2007) In Clinical Allergy 37(9). p.5-1320
Abstract

BACKGROUND: Asthma is a common disabling condition, with known environmental and familial risk factors and with their assumed interactions. We wanted to carry out a family study on asthma to address gene-environment interactions at a population level.

METHODS: We conducted a nation-wide study on familial risks for asthma. An asthma database was constructed by linking the Multigeneration Register on 0-72-year-old subjects to the Hospital Discharge Register for diagnosed asthma cases in Sweden from years 1987 to 2004. Standardized incidence ratios (SIRs) were calculated for affected singleton siblings, twins and spouses by comparing with those whose siblings or spouses had no asthma.

RESULTS: A total of 67 370 hospitalized... (More)

BACKGROUND: Asthma is a common disabling condition, with known environmental and familial risk factors and with their assumed interactions. We wanted to carry out a family study on asthma to address gene-environment interactions at a population level.

METHODS: We conducted a nation-wide study on familial risks for asthma. An asthma database was constructed by linking the Multigeneration Register on 0-72-year-old subjects to the Hospital Discharge Register for diagnosed asthma cases in Sweden from years 1987 to 2004. Standardized incidence ratios (SIRs) were calculated for affected singleton siblings, twins and spouses by comparing with those whose siblings or spouses had no asthma.

RESULTS: A total of 67 370 hospitalized cases and 5638 affected siblings were identified with a familial SIR of 3.70, which was independent of sex, diagnostic age and age differences between the siblings. The SIR for different-sex twins was 5.17 and for same-sex twins it was 13.38. There was a low correlation between spouses for asthma.

CONCLUSIONS: Asthma shows a higher familial risk than many common diseases. The higher difference in familial excess risk between singleton siblings and different-sex twins provides strong genetic epidemiological evidence for gene-environment interactions in asthma. The concept of gene-environment interactions needs to be accommodated in future aetiological studies on asthma. Data on environmental factors and family history are important for clinical risk estimation.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Asthma/epidemiology, Child, Child, Preschool, Diseases in Twins, Female, Genetic Predisposition to Disease, Hospitalization/statistics & numerical data, Humans, Infant, Infant, Newborn, Male, Middle Aged, Registries, Risk Assessment, Risk Factors, Siblings, Sweden/epidemiology
in
Clinical Allergy
volume
37
issue
9
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:17845412
  • scopus:34548513330
ISSN
0954-7894
DOI
10.1111/j.1365-2222.2007.02737.x
language
English
LU publication?
no
id
81272101-d10c-422a-a68d-66f23d8171b5
date added to LUP
2019-01-30 11:06:08
date last changed
2020-01-13 01:25:12
@article{81272101-d10c-422a-a68d-66f23d8171b5,
  abstract     = {<p>BACKGROUND: Asthma is a common disabling condition, with known environmental and familial risk factors and with their assumed interactions. We wanted to carry out a family study on asthma to address gene-environment interactions at a population level.</p><p>METHODS: We conducted a nation-wide study on familial risks for asthma. An asthma database was constructed by linking the Multigeneration Register on 0-72-year-old subjects to the Hospital Discharge Register for diagnosed asthma cases in Sweden from years 1987 to 2004. Standardized incidence ratios (SIRs) were calculated for affected singleton siblings, twins and spouses by comparing with those whose siblings or spouses had no asthma.</p><p>RESULTS: A total of 67 370 hospitalized cases and 5638 affected siblings were identified with a familial SIR of 3.70, which was independent of sex, diagnostic age and age differences between the siblings. The SIR for different-sex twins was 5.17 and for same-sex twins it was 13.38. There was a low correlation between spouses for asthma.</p><p>CONCLUSIONS: Asthma shows a higher familial risk than many common diseases. The higher difference in familial excess risk between singleton siblings and different-sex twins provides strong genetic epidemiological evidence for gene-environment interactions in asthma. The concept of gene-environment interactions needs to be accommodated in future aetiological studies on asthma. Data on environmental factors and family history are important for clinical risk estimation.</p>},
  author       = {Hemminki, K and Li, X and Sundquist, K and Sundquist, J},
  issn         = {0954-7894},
  language     = {eng},
  number       = {9},
  pages        = {5--1320},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Allergy},
  title        = {Familial risks for asthma among twins and other siblings based on hospitalizations in Sweden},
  url          = {http://dx.doi.org/10.1111/j.1365-2222.2007.02737.x},
  doi          = {10.1111/j.1365-2222.2007.02737.x},
  volume       = {37},
  year         = {2007},
}