Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.
Maziarz, M LU ; Hagopian, W ; Palmer, J P ; Sanjeevi, C B ; Kockum, I ; Breslow, N and Lernmark, Åke LU
(2015)
In Genes and Immunity
16(8).
p.541-551
- Abstract
- The possible interrelations between human leukocyte antigen (HLA)-DQ, non-HLA single-nucleotide polymorphisms (SNPs) and islet autoantibodies were investigated at clinical onset in 1-34-year-old type 1 diabetes (T1D) patients (n=305) and controls (n=203). Among the non-HLA SNPs reported by the Type 1 Diabetes Genetics Consortium, 24% were supported in this Swedish replication set including that the increased risk of minor PTPN22 allele and high-risk HLA was modified by GAD65 autoantibodies. The association between T1D and the minor AA+AC genotype in ERBB3 gene was stronger among IA-2 autoantibody-positive patients (comparison P=0.047). The association between T1D and the common insulin (AA) genotype was stronger among insulin autoantibody... (More)
- The possible interrelations between human leukocyte antigen (HLA)-DQ, non-HLA single-nucleotide polymorphisms (SNPs) and islet autoantibodies were investigated at clinical onset in 1-34-year-old type 1 diabetes (T1D) patients (n=305) and controls (n=203). Among the non-HLA SNPs reported by the Type 1 Diabetes Genetics Consortium, 24% were supported in this Swedish replication set including that the increased risk of minor PTPN22 allele and high-risk HLA was modified by GAD65 autoantibodies. The association between T1D and the minor AA+AC genotype in ERBB3 gene was stronger among IA-2 autoantibody-positive patients (comparison P=0.047). The association between T1D and the common insulin (AA) genotype was stronger among insulin autoantibody (IAA)-positive patients (comparison P=0.008). In contrast, the association between T1D and unidentified 26471 gene was stronger among IAA-negative (comparison P=0.049) and IA-2 autoantibody-negative (comparison P=0.052) patients. Finally, the association between IL2RA and T1D was stronger among IAA-positive than among IAA-negative patients (comparison P=0.028). These results suggest that the increased risk of T1D by non-HLA genes is often modified by both islet autoantibodies and HLA-DQ. The interactions between non-HLA genes, islet autoantibodies and HLA-DQ should be taken into account in T1D prediction studies as well as in prevention trials aimed at inducing immunological tolerance to islet autoantigens.Genes and Immunity advance online publication, 29 October 2015; doi:10.1038/gene.2015.43. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8147939
- author
- Maziarz, M
LU
; Hagopian, W
; Palmer, J P
; Sanjeevi, C B
; Kockum, I
; Breslow, N
and Lernmark, Åke
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes and Immunity
- volume
- 16
- issue
- 8
- pages
- 541 - 551
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:26513234
- wos:000365976200006
- scopus:84949107978
- pmid:26513234
- ISSN
- 1476-5470
- DOI
- 10.1038/gene.2015.43
- language
- English
- LU publication?
- yes
- id
- 756b605c-2545-43e7-ab6e-4476e91800a7 (old id 8147939)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26513234?dopt=Abstract
- date added to LUP
- 2016-04-01 10:10:19
- date last changed
- 2022-04-04 03:03:07
@article{756b605c-2545-43e7-ab6e-4476e91800a7,
abstract = {{The possible interrelations between human leukocyte antigen (HLA)-DQ, non-HLA single-nucleotide polymorphisms (SNPs) and islet autoantibodies were investigated at clinical onset in 1-34-year-old type 1 diabetes (T1D) patients (n=305) and controls (n=203). Among the non-HLA SNPs reported by the Type 1 Diabetes Genetics Consortium, 24% were supported in this Swedish replication set including that the increased risk of minor PTPN22 allele and high-risk HLA was modified by GAD65 autoantibodies. The association between T1D and the minor AA+AC genotype in ERBB3 gene was stronger among IA-2 autoantibody-positive patients (comparison P=0.047). The association between T1D and the common insulin (AA) genotype was stronger among insulin autoantibody (IAA)-positive patients (comparison P=0.008). In contrast, the association between T1D and unidentified 26471 gene was stronger among IAA-negative (comparison P=0.049) and IA-2 autoantibody-negative (comparison P=0.052) patients. Finally, the association between IL2RA and T1D was stronger among IAA-positive than among IAA-negative patients (comparison P=0.028). These results suggest that the increased risk of T1D by non-HLA genes is often modified by both islet autoantibodies and HLA-DQ. The interactions between non-HLA genes, islet autoantibodies and HLA-DQ should be taken into account in T1D prediction studies as well as in prevention trials aimed at inducing immunological tolerance to islet autoantigens.Genes and Immunity advance online publication, 29 October 2015; doi:10.1038/gene.2015.43.}},
author = {{Maziarz, M and Hagopian, W and Palmer, J P and Sanjeevi, C B and Kockum, I and Breslow, N and Lernmark, Åke}},
issn = {{1476-5470}},
language = {{eng}},
number = {{8}},
pages = {{541--551}},
publisher = {{Nature Publishing Group}},
series = {{Genes and Immunity}},
title = {{Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.}},
url = {{http://dx.doi.org/10.1038/gene.2015.43}},
doi = {{10.1038/gene.2015.43}},
volume = {{16}},
year = {{2015}},
}