Advanced

c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.

Bush, Matthew J; Tschowri, Natalia; Schlimpert, Susan; Flärdh, Klas LU and Buttner, Mark J (2015) In Nature Reviews. Microbiology 13(12). p.749-760
Abstract
The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator... (More)
The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews. Microbiology
volume
13
issue
12
pages
749 - 760
publisher
Nature Publishing Group
external identifiers
  • pmid:26499894
  • wos:000365839200005
  • scopus:84947486837
ISSN
1740-1534
DOI
10.1038/nrmicro3546
language
English
LU publication?
yes
id
9530e159-9d6d-44b3-bdd8-6c9987df3a9f (old id 8148385)
date added to LUP
2015-11-17 11:05:55
date last changed
2017-10-29 03:23:57
@article{9530e159-9d6d-44b3-bdd8-6c9987df3a9f,
  abstract     = {The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.},
  author       = {Bush, Matthew J and Tschowri, Natalia and Schlimpert, Susan and Flärdh, Klas and Buttner, Mark J},
  issn         = {1740-1534},
  language     = {eng},
  number       = {12},
  pages        = {749--760},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews. Microbiology},
  title        = {c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.},
  url          = {http://dx.doi.org/10.1038/nrmicro3546},
  volume       = {13},
  year         = {2015},
}