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A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.

Su, Jing; Ekman, Carl LU ; Oskolkov, Nikolay LU ; Lahti, Leo; Ström, Kristoffer LU ; Brazma, Alvis; Groop, Leif LU ; Rung, Johan and Hansson, Ola LU (2015) In Skeletal Muscle 5.
Abstract
Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Skeletal Muscle
volume
5
publisher
BioMed Central
external identifiers
  • pmid:26457177
  • wos:000362548600002
  • scopus:84943536506
ISSN
2044-5040
DOI
10.1186/s13395-015-0059-1
language
English
LU publication?
yes
id
1459c3ee-9cf1-4afe-9ab9-9de132733fcb (old id 8152565)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26457177?dopt=Abstract
date added to LUP
2015-11-03 11:41:45
date last changed
2017-10-08 04:00:31
@article{1459c3ee-9cf1-4afe-9ab9-9de132733fcb,
  abstract     = {Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.},
  articleno    = {35},
  author       = {Su, Jing and Ekman, Carl and Oskolkov, Nikolay and Lahti, Leo and Ström, Kristoffer and Brazma, Alvis and Groop, Leif and Rung, Johan and Hansson, Ola},
  issn         = {2044-5040},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Skeletal Muscle},
  title        = {A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.},
  url          = {http://dx.doi.org/10.1186/s13395-015-0059-1},
  volume       = {5},
  year         = {2015},
}