A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.
Su, Jing ; Ekman, Carl LU ; Oskolkov, Nikolay LU ; Lahti, Leo ; Ström, Kristoffer LU ; Brazma, Alvis ; Groop, Leif LU ; Rung, Johan and Hansson, Ola LU
(2015)
In Skeletal Muscle
5.
- Abstract
- Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8152565
- author
- Su, Jing
; Ekman, Carl
LU
; Oskolkov, Nikolay
LU
; Lahti, Leo
; Ström, Kristoffer
LU
; Brazma, Alvis
; Groop, Leif
LU
; Rung, Johan
and Hansson, Ola
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Skeletal Muscle
- volume
- 5
- article number
- 35
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26457177
- wos:000362548600002
- scopus:84943536506
- pmid:26457177
- ISSN
- 2044-5040
- DOI
- 10.1186/s13395-015-0059-1
- language
- English
- LU publication?
- yes
- id
- 1459c3ee-9cf1-4afe-9ab9-9de132733fcb (old id 8152565)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26457177?dopt=Abstract
- date added to LUP
- 2016-04-01 14:15:42
- date last changed
- 2024-04-10 17:53:55
@article{1459c3ee-9cf1-4afe-9ab9-9de132733fcb,
abstract = {{Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.}},
author = {{Su, Jing and Ekman, Carl and Oskolkov, Nikolay and Lahti, Leo and Ström, Kristoffer and Brazma, Alvis and Groop, Leif and Rung, Johan and Hansson, Ola}},
issn = {{2044-5040}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Skeletal Muscle}},
title = {{A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.}},
url = {{https://lup.lub.lu.se/search/files/3875337/8840901}},
doi = {{10.1186/s13395-015-0059-1}},
volume = {{5}},
year = {{2015}},
}