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Search for familial clustering of multiple myeloma with any cancer.

Frank, C; Fallah, M; Chen, T; Mai, E K; Sundquist, Jan LU ; Försti, Asta LU and Hemminki, Kari LU (2016) In Leukemia 30. p.627-632
Abstract
Multiple myeloma (MM) is a disease of immunoglobulin producing plasma cells which reside mainly in the bone marrow. Family members of MM patients are at a risk of MM but whether other malignancies are in excess in family members is not established and is the aim of this study. MM patients (24,137) were identified from the Swedish Cancer Registry from years 1958-2012. Relative risks (RRs) were calculated for MM defined by any cancer diagnosed in first degree relatives and compared to individuals whose relatives had no cancer. MM was reliably associated with relative's colorectal, breast and prostate cancers, non-thyroid endocrine tumors, leukemia and cancer of unknown primary; additionally MM was associated with subsites of bone and... (More)
Multiple myeloma (MM) is a disease of immunoglobulin producing plasma cells which reside mainly in the bone marrow. Family members of MM patients are at a risk of MM but whether other malignancies are in excess in family members is not established and is the aim of this study. MM patients (24,137) were identified from the Swedish Cancer Registry from years 1958-2012. Relative risks (RRs) were calculated for MM defined by any cancer diagnosed in first degree relatives and compared to individuals whose relatives had no cancer. MM was reliably associated with relative's colorectal, breast and prostate cancers, non-thyroid endocrine tumors, leukemia and cancer of unknown primary; additionally MM was associated with subsites of bone and connective tissue tumors and of non-Hodgkin lymphoma, including lymphoplasmacytic lymphoma/Waldenström macroglobulinema (RR 3.47). MM showed a strong association (RR 1.91) in colorectal cancer families, possibly as part of an unidentified syndrome. All the associations of MM with discordant cancers are novel suggesting that MM shares genetic susceptibility with many cancers. The associations of MM bone and connective tissue tumors were supported by at least two independent results. Whether the results signal bone-related biology shared by MM and these tumors deserves further study.Leukemia accepted article preview online, 09 October 2015. doi:10.1038/leu.2015.279. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Leukemia
volume
30
pages
627 - 632
publisher
Nature Publishing Group
external identifiers
  • pmid:26449663
  • scopus:84959348100
  • wos:000371688500012
ISSN
1476-5551
DOI
10.1038/leu.2015.279
language
English
LU publication?
yes
id
10c56b49-4204-476a-bc18-797a639917af (old id 8158531)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26449663?dopt=Abstract
date added to LUP
2015-11-02 21:11:31
date last changed
2017-04-23 04:38:59
@article{10c56b49-4204-476a-bc18-797a639917af,
  abstract     = {Multiple myeloma (MM) is a disease of immunoglobulin producing plasma cells which reside mainly in the bone marrow. Family members of MM patients are at a risk of MM but whether other malignancies are in excess in family members is not established and is the aim of this study. MM patients (24,137) were identified from the Swedish Cancer Registry from years 1958-2012. Relative risks (RRs) were calculated for MM defined by any cancer diagnosed in first degree relatives and compared to individuals whose relatives had no cancer. MM was reliably associated with relative's colorectal, breast and prostate cancers, non-thyroid endocrine tumors, leukemia and cancer of unknown primary; additionally MM was associated with subsites of bone and connective tissue tumors and of non-Hodgkin lymphoma, including lymphoplasmacytic lymphoma/Waldenström macroglobulinema (RR 3.47). MM showed a strong association (RR 1.91) in colorectal cancer families, possibly as part of an unidentified syndrome. All the associations of MM with discordant cancers are novel suggesting that MM shares genetic susceptibility with many cancers. The associations of MM bone and connective tissue tumors were supported by at least two independent results. Whether the results signal bone-related biology shared by MM and these tumors deserves further study.Leukemia accepted article preview online, 09 October 2015. doi:10.1038/leu.2015.279.},
  author       = {Frank, C and Fallah, M and Chen, T and Mai, E K and Sundquist, Jan and Försti, Asta and Hemminki, Kari},
  issn         = {1476-5551},
  language     = {eng},
  pages        = {627--632},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {Search for familial clustering of multiple myeloma with any cancer.},
  url          = {http://dx.doi.org/10.1038/leu.2015.279},
  volume       = {30},
  year         = {2016},
}