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Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.

Wennström, Malin LU ; Hall, Sara LU ; Nägga, Katarina LU ; Londos, Elisabet LU ; Minthon, Lennart LU and Hansson, Oskar LU (2015) In Alzheimer's Research & Therapy 7(1).
Abstract
Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's Research & Therapy
volume
7
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26434635
  • wos:000362245500001
  • scopus:84942940978
ISSN
1758-9193
DOI
10.1186/s13195-015-0145-y
language
English
LU publication?
yes
id
528c0432-c4c2-4a70-b473-aad8bf9a8375 (old id 8158947)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26434635?dopt=Abstract
date added to LUP
2015-11-02 17:18:09
date last changed
2017-01-01 05:41:06
@article{528c0432-c4c2-4a70-b473-aad8bf9a8375,
  abstract     = {Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.},
  articleno    = {63},
  author       = {Wennström, Malin and Hall, Sara and Nägga, Katarina and Londos, Elisabet and Minthon, Lennart and Hansson, Oskar},
  issn         = {1758-9193},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Alzheimer's Research & Therapy},
  title        = {Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.},
  url          = {http://dx.doi.org/10.1186/s13195-015-0145-y},
  volume       = {7},
  year         = {2015},
}