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RIFM fragrance ingredient safety assessment, linalyl isobutyrate, CAS registry number 78-35-3.

Api, A M; Belsito, D; Bhatia, S; Bruze, Magnus LU ; Calow, P; Dagli, M L; Dekant, W; Fryer, A D; Kromidas, L and La Cava, S, et al. (2015) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was based on the Threshold of Toxicological Concern (TTC) of 0.03 mg/kg/day for a Cramer Class I material. The estimated systemic exposure is determined to be below this value while assuming 80% absorption from skin contact and 100% from inhalation. A systemic exposure below the TTC value is acceptable.
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published
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
publisher
Elsevier
external identifiers
  • PMID:26423640
  • Scopus:84955396175
ISSN
1873-6351
DOI
10.1016/j.fct.2015.09.013
language
English
LU publication?
yes
id
34a1bb37-9a3b-45d7-8064-91df18bb565e (old id 8159885)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26423640?dopt=Abstract
date added to LUP
2015-11-02 14:47:29
date last changed
2017-01-01 07:44:55
@article{34a1bb37-9a3b-45d7-8064-91df18bb565e,
  abstract     = {The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was based on the Threshold of Toxicological Concern (TTC) of 0.03 mg/kg/day for a Cramer Class I material. The estimated systemic exposure is determined to be below this value while assuming 80% absorption from skin contact and 100% from inhalation. A systemic exposure below the TTC value is acceptable.},
  author       = {Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and La Cava, S and Lalko, J F and Lapczynski, A and Liebler, D C and Miyachi, Y and Politano, V T and Ritacco, G and Salvito, D and Schultz, T W and Shen, J and Sipes, I G and Wall, B and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  month        = {09},
  publisher    = {Elsevier},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, linalyl isobutyrate, CAS registry number 78-35-3.},
  url          = {http://dx.doi.org/10.1016/j.fct.2015.09.013},
  year         = {2015},
}