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Interaction between VWF and FVIII in treating VWD

Miesbach, Wolfgang and Berntorp, Erik LU (2015) In European Journal of Haematology 95(5). p.449-454
Abstract
In patients with von Willebrand disease (VWD), the absence of von Willebrand factor (VWF) antigen leads to the premature loss of endogenous circulating secreted factor VIII (FVIII), thereby resulting in the dual defect in haemostasis. Consequently, correcting the VWF deficiency also acts to correct the associated defect in FVIII activity because exogenous VWF forms complexes with and protects endogenous FVIII. The purpose of this study was to summarise relevant aspects of the interaction between VWF and FVIII and to analyse their effects on VWD treatment. Differences in the VWF/FVIII ratios in coagulation factor concentrates should be considered when treating VWD.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
von Willebrand disease, von Willebrand factor, factor VIII, haemophilia, A
in
European Journal of Haematology
volume
95
issue
5
pages
449 - 454
publisher
Wiley-Blackwell
external identifiers
  • wos:000363328800010
  • scopus:84944511868
ISSN
1600-0609
DOI
10.1111/ejh.12514
language
English
LU publication?
yes
id
02799fff-d1e8-49cf-a9e3-63ac76723320 (old id 8195246)
date added to LUP
2015-12-01 07:08:35
date last changed
2017-01-22 03:03:06
@article{02799fff-d1e8-49cf-a9e3-63ac76723320,
  abstract     = {In patients with von Willebrand disease (VWD), the absence of von Willebrand factor (VWF) antigen leads to the premature loss of endogenous circulating secreted factor VIII (FVIII), thereby resulting in the dual defect in haemostasis. Consequently, correcting the VWF deficiency also acts to correct the associated defect in FVIII activity because exogenous VWF forms complexes with and protects endogenous FVIII. The purpose of this study was to summarise relevant aspects of the interaction between VWF and FVIII and to analyse their effects on VWD treatment. Differences in the VWF/FVIII ratios in coagulation factor concentrates should be considered when treating VWD.},
  author       = {Miesbach, Wolfgang and Berntorp, Erik},
  issn         = {1600-0609},
  keyword      = {von Willebrand disease,von Willebrand factor,factor VIII,haemophilia,A},
  language     = {eng},
  number       = {5},
  pages        = {449--454},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Interaction between VWF and FVIII in treating VWD},
  url          = {http://dx.doi.org/10.1111/ejh.12514},
  volume       = {95},
  year         = {2015},
}