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Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path

Wieloch, T. LU ; Lindvall, O. LU ; Blomqvist, P. and Gage, F. H. (1985) In Neurological Research 7(1). p.24-26
Abstract
The effect of lesions of two excitatory afferent pathways on the cellular damage in the hippocampus following complete cerebral ischaemia was investigated in the rat Lesions transecting the perforant path led to a significant decrease in cellular damage in the hippocampal CA1 region ipsilateral to the lesion as compared to the contatterai side and to control. Lesions of the fimbria-fornix, on the other hand, had no significant effects. We propose that the protective effect of the perforant path lesions is due to removal of glutamatergic/aspartergic pathways and that release of these excitatory amino acids might be a critical factor for neuronal necrosis following cerebral ischaemia.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurological Research
volume
7
issue
1
pages
3 pages
publisher
Butterworth-Heinemann
external identifiers
  • scopus:0021916489
ISSN
0161-6412
DOI
10.1080/01616412.1985.11739695
language
English
LU publication?
yes
id
81cee870-d1db-4eb7-b5a9-e7f06312b229
date added to LUP
2019-06-13 17:20:39
date last changed
2019-09-17 13:14:27
@article{81cee870-d1db-4eb7-b5a9-e7f06312b229,
  abstract     = {The effect of lesions of two excitatory afferent pathways on the cellular damage in the hippocampus following complete cerebral ischaemia was investigated in the rat Lesions transecting the perforant path led to a significant decrease in cellular damage in the hippocampal CA1 region ipsilateral to the lesion as compared to the contatterai side and to control. Lesions of the fimbria-fornix, on the other hand, had no significant effects. We propose that the protective effect of the perforant path lesions is due to removal of glutamatergic/aspartergic pathways and that release of these excitatory amino acids might be a critical factor for neuronal necrosis following cerebral ischaemia.},
  author       = {Wieloch, T. and Lindvall, O. and Blomqvist, P. and Gage, F. H.},
  issn         = {0161-6412},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {24--26},
  publisher    = {Butterworth-Heinemann},
  series       = {Neurological Research},
  title        = {Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path},
  url          = {http://dx.doi.org/10.1080/01616412.1985.11739695},
  volume       = {7},
  year         = {1985},
}