Advanced

Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease.

Mccourt, Andy LU ; O'Donovan, Kirsty L; Ekblad, Eva LU ; Sand, Elin LU ; Craufurd, David; Rosser, Anne; Sanders, David; Stoy, Nicholas; Rickards, Hugh and Wierup, Nils LU , et al. (2015) In PLoS Currents 7.
Abstract
Weight loss is an important complication of Huntington's disease (HD), however the mechanism for weight loss in HD is not entirely understood. Mutant huntingtin is expressed in the gastrointestinal (GI) tract and, in HD mice, mutant huntingtin inclusions are found within the enteric nervous system along the GI tract. A reduction of neuropeptides, decreased mucosal thickness and villus length, as well as gut motility impairment, have also been shown in HD mice. We therefore set out to study gastric mucosa of patients with HD, looking for abnormalities of mucosal cells using immunohistochemistry. In order to investigate possible histological differences related to gastric acid production, we evaluated the cell density of acid producing... (More)
Weight loss is an important complication of Huntington's disease (HD), however the mechanism for weight loss in HD is not entirely understood. Mutant huntingtin is expressed in the gastrointestinal (GI) tract and, in HD mice, mutant huntingtin inclusions are found within the enteric nervous system along the GI tract. A reduction of neuropeptides, decreased mucosal thickness and villus length, as well as gut motility impairment, have also been shown in HD mice. We therefore set out to study gastric mucosa of patients with HD, looking for abnormalities of mucosal cells using immunohistochemistry. In order to investigate possible histological differences related to gastric acid production, we evaluated the cell density of acid producing parietal cells, as well as gastrin producing cells (the endocrine cell controlling parietal cell function). In addition, we looked at chief cells and somatostatin-containing cells. In gastric mucosa from HD subjects, compared to control subject biopsies, a reduced expression of gastrin (a marker of G cells) was found. This is in line with previous HD mouse studies showing reduction of GI tract neuropeptides. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Currents
volume
7
publisher
Public Library of Science
external identifiers
  • pmid:26581667
  • scopus:84958580999
ISSN
2157-3999
DOI
10.1371/currents.hd.858b4cc7f235df068387e9c20c436a79
language
English
LU publication?
yes
id
b97b5a4c-209a-4967-9b65-d8ff30ff1b0e (old id 8235202)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26581667?dopt=Abstract
date added to LUP
2015-12-05 19:00:22
date last changed
2017-01-22 03:58:27
@article{b97b5a4c-209a-4967-9b65-d8ff30ff1b0e,
  abstract     = {Weight loss is an important complication of Huntington's disease (HD), however the mechanism for weight loss in HD is not entirely understood. Mutant huntingtin is expressed in the gastrointestinal (GI) tract and, in HD mice, mutant huntingtin inclusions are found within the enteric nervous system along the GI tract. A reduction of neuropeptides, decreased mucosal thickness and villus length, as well as gut motility impairment, have also been shown in HD mice. We therefore set out to study gastric mucosa of patients with HD, looking for abnormalities of mucosal cells using immunohistochemistry. In order to investigate possible histological differences related to gastric acid production, we evaluated the cell density of acid producing parietal cells, as well as gastrin producing cells (the endocrine cell controlling parietal cell function). In addition, we looked at chief cells and somatostatin-containing cells. In gastric mucosa from HD subjects, compared to control subject biopsies, a reduced expression of gastrin (a marker of G cells) was found. This is in line with previous HD mouse studies showing reduction of GI tract neuropeptides.},
  author       = {Mccourt, Andy and O'Donovan, Kirsty L and Ekblad, Eva and Sand, Elin and Craufurd, David and Rosser, Anne and Sanders, David and Stoy, Nicholas and Rickards, Hugh and Wierup, Nils and Bates, Gillian P and Björkqvist, Maria and Quarrell, Oliver},
  issn         = {2157-3999},
  language     = {eng},
  publisher    = {Public Library of Science},
  series       = {PLoS Currents},
  title        = {Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease.},
  url          = {http://dx.doi.org/10.1371/currents.hd.858b4cc7f235df068387e9c20c436a79},
  volume       = {7},
  year         = {2015},
}