Advanced

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.

Kovatcheva-Datchary, Petia; Nilsson, Anne LU ; Akrami, Rozita; Lee, Ying Shiuan; De Vadder, Filipe; Arora, Tulika; Hallen, Anna; Martens, Eric; Björck, Inger LU and Bäckhed, Fredrik (2015) In Cell Metabolism 22(6). p.971-982
Abstract
The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors... (More)
The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Metabolism
volume
22
issue
6
pages
971 - 982
publisher
Cell Press
external identifiers
  • pmid:26552345
  • wos:000365993100006
  • scopus:84949491459
ISSN
1550-4131
DOI
10.1016/j.cmet.2015.10.001
language
English
LU publication?
yes
id
7b1f63a1-6ec8-42cf-93d8-8c0d8b642fea (old id 8236222)
date added to LUP
2015-12-07 14:22:25
date last changed
2017-11-12 03:10:26
@article{7b1f63a1-6ec8-42cf-93d8-8c0d8b642fea,
  abstract     = {The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.},
  author       = {Kovatcheva-Datchary, Petia and Nilsson, Anne and Akrami, Rozita and Lee, Ying Shiuan and De Vadder, Filipe and Arora, Tulika and Hallen, Anna and Martens, Eric and Björck, Inger and Bäckhed, Fredrik},
  issn         = {1550-4131},
  language     = {eng},
  number       = {6},
  pages        = {971--982},
  publisher    = {Cell Press},
  series       = {Cell Metabolism},
  title        = {Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.},
  url          = {http://dx.doi.org/10.1016/j.cmet.2015.10.001},
  volume       = {22},
  year         = {2015},
}