Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.
(2015) In Cell Metabolism 22(6). p.971-982- Abstract
- The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors... (More)
- The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8236222
- author
- Kovatcheva-Datchary, Petia
; Nilsson, Anne
LU
; Akrami, Rozita ; Lee, Ying Shiuan ; De Vadder, Filipe ; Arora, Tulika ; Hallen, Anna ; Martens, Eric ; Björck, Inger LU and Bäckhed, Fredrik
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Metabolism
- volume
- 22
- issue
- 6
- pages
- 971 - 982
- publisher
- Cell Press
- external identifiers
-
- pmid:26552345
- wos:000365993100006
- scopus:84949491459
- pmid:26552345
- ISSN
- 1550-4131
- DOI
- 10.1016/j.cmet.2015.10.001
- project
- ANTIDIABETIC FOOD CENTRE
- language
- English
- LU publication?
- yes
- id
- 7b1f63a1-6ec8-42cf-93d8-8c0d8b642fea (old id 8236222)
- date added to LUP
- 2016-04-01 10:39:11
- date last changed
- 2022-12-25 06:40:00
@article{7b1f63a1-6ec8-42cf-93d8-8c0d8b642fea, abstract = {{The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.}}, author = {{Kovatcheva-Datchary, Petia and Nilsson, Anne and Akrami, Rozita and Lee, Ying Shiuan and De Vadder, Filipe and Arora, Tulika and Hallen, Anna and Martens, Eric and Björck, Inger and Bäckhed, Fredrik}}, issn = {{1550-4131}}, language = {{eng}}, number = {{6}}, pages = {{971--982}}, publisher = {{Cell Press}}, series = {{Cell Metabolism}}, title = {{Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.}}, url = {{http://dx.doi.org/10.1016/j.cmet.2015.10.001}}, doi = {{10.1016/j.cmet.2015.10.001}}, volume = {{22}}, year = {{2015}}, }