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Neurogenesis following Stroke Affecting the Adult Brain.

Lindvall, Olle LU and Kokaia, Zaal LU (2015) In Cold Spring Harbor perspectives in biology 7(11). p.019034-019034
Abstract
A bulk of experimental evidence supports the idea that the stroke-damaged adult brain makes an attempt to repair itself by producing new neurons also in areas where neurogenesis does not normally occur (e.g., the striatum and cerebral cortex). Knowledge about mechanisms regulating the different steps of neurogenesis after stroke is rapidly increasing but still incomplete. The functional consequences of stroke-induced neurogenesis and the level of integration of the new neurons into existing neural circuitries are poorly understood. To have a substantial impact on the recovery after stroke, this potential mechanism for self-repair needs to be enhanced, primarily by increasing the survival and differentiation of the generated neuroblasts.... (More)
A bulk of experimental evidence supports the idea that the stroke-damaged adult brain makes an attempt to repair itself by producing new neurons also in areas where neurogenesis does not normally occur (e.g., the striatum and cerebral cortex). Knowledge about mechanisms regulating the different steps of neurogenesis after stroke is rapidly increasing but still incomplete. The functional consequences of stroke-induced neurogenesis and the level of integration of the new neurons into existing neural circuitries are poorly understood. To have a substantial impact on the recovery after stroke, this potential mechanism for self-repair needs to be enhanced, primarily by increasing the survival and differentiation of the generated neuroblasts. Moreover, for efficient repair, optimization of neurogenesis most likely needs to be combined with promotion of other endogenous neuroregenerative responses (e.g., protection and sprouting of remaining mature neurons, transplantation of neural stem/progenitor cells [NSPC]-derived neurons and glia cells, and modulation of inflammation). (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cold Spring Harbor perspectives in biology
volume
7
issue
11
pages
019034 - 019034
publisher
Cold Spring Harbor Laboratory Press
external identifiers
  • pmid:26525150
  • wos:000368535700004
  • scopus:84946423581
ISSN
1943-0264
DOI
10.1101/cshperspect.a019034
language
English
LU publication?
yes
id
5969c27c-f1eb-4212-a7a3-95b3c08f2f31 (old id 8243637)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26525150?dopt=Abstract
date added to LUP
2015-12-01 20:11:26
date last changed
2017-11-19 03:46:28
@article{5969c27c-f1eb-4212-a7a3-95b3c08f2f31,
  abstract     = {A bulk of experimental evidence supports the idea that the stroke-damaged adult brain makes an attempt to repair itself by producing new neurons also in areas where neurogenesis does not normally occur (e.g., the striatum and cerebral cortex). Knowledge about mechanisms regulating the different steps of neurogenesis after stroke is rapidly increasing but still incomplete. The functional consequences of stroke-induced neurogenesis and the level of integration of the new neurons into existing neural circuitries are poorly understood. To have a substantial impact on the recovery after stroke, this potential mechanism for self-repair needs to be enhanced, primarily by increasing the survival and differentiation of the generated neuroblasts. Moreover, for efficient repair, optimization of neurogenesis most likely needs to be combined with promotion of other endogenous neuroregenerative responses (e.g., protection and sprouting of remaining mature neurons, transplantation of neural stem/progenitor cells [NSPC]-derived neurons and glia cells, and modulation of inflammation).},
  author       = {Lindvall, Olle and Kokaia, Zaal},
  issn         = {1943-0264},
  language     = {eng},
  number       = {11},
  pages        = {019034--019034},
  publisher    = {Cold Spring Harbor Laboratory Press},
  series       = {Cold Spring Harbor perspectives in biology},
  title        = {Neurogenesis following Stroke Affecting the Adult Brain.},
  url          = {http://dx.doi.org/10.1101/cshperspect.a019034},
  volume       = {7},
  year         = {2015},
}