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Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters

Kisiel, Marta A. ; Cai, Gui Hong ; Sjögren, Madeleine Petersson LU ; Löndahl, Jakob LU orcid ; Jakobsson, Jonas LU ; Wollmer, Per LU ; Malinovschi, Andrei LU and Svartengren, Magnus (2023) In ERJ open research 9(2).
Abstract

Introduction Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early pulmonary changes and enable prevention. The aim of the present study was to evaluate whether AiDA detects changes in the most peripheral airways of firefighters. Methods AiDA, measuring the effective airspace radius (rAiDA) and zero-second recovery (R0), was used as a complement to other standardised lung function... (More)

Introduction Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early pulmonary changes and enable prevention. The aim of the present study was to evaluate whether AiDA detects changes in the most peripheral airways of firefighters. Methods AiDA, measuring the effective airspace radius (rAiDA) and zero-second recovery (R0), was used as a complement to other standardised lung function measures in 21 male firefighters and 16 age-matched male controls. Results There were significant differences in rAiDA and R0 between firefighters (mean±SD rAiDA 0.301±0.024 mm; mean±SD R0 0.336±0.116 arbitrary units) and controls (mean±SD rAiDA 0.276±0.044 mm; mean±SD R0 0.5760.168 arbitrary units), p=0.03 and p<0.001, respectively. Higher forced vital capacity was found in firefighters (mean 101% of predicted) than in controls (mean 93% of predicted; p=0.03). No significant differences were found with regard to either the ratio between forced expiratory volume in 1 s and forced vital capacity or forced expiratory volume in 1 s. The majority of firefighters had diffusing capacity of the lung for carbon monoxide, oscillometry and single-breath nitrogen washout values within the normal ranges. Conclusion AiDA parameters can provide information on early pulmonary peripheral changes that may not be seen with standard techniques used in screening of pulmonary function.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERJ open research
volume
9
issue
2
article number
00504-2022
pages
8 pages
publisher
European Respiratory Society
external identifiers
  • pmid:37057087
  • scopus:85152973657
ISSN
2312-0541
DOI
10.1183/23120541.00504-2022
language
English
LU publication?
yes
additional info
Funding Information: Support statement: This work was supported by the Swedish Heart and Lung Foundation (grant numbers 2020– 0617 and 2020-0855), the Swedish Research Council for Health, Working Life and Welfare (grant number 2017-00690), and the Swedish Research Council (Vetenskapsrådet) (grant number 2021-03265). Funding information for this article has been deposited with the Crossref Funder Registry. Publisher Copyright: © The authors 2023.
id
82f3dc57-d3dc-4542-92cc-509dad125489
date added to LUP
2023-11-08 16:25:09
date last changed
2024-04-20 08:30:41
@article{82f3dc57-d3dc-4542-92cc-509dad125489,
  abstract     = {{<p>Introduction Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early pulmonary changes and enable prevention. The aim of the present study was to evaluate whether AiDA detects changes in the most peripheral airways of firefighters. Methods AiDA, measuring the effective airspace radius (r<sub>AiDA</sub>) and zero-second recovery (R<sub>0</sub>), was used as a complement to other standardised lung function measures in 21 male firefighters and 16 age-matched male controls. Results There were significant differences in r<sub>AiDA</sub> and R<sub>0</sub> between firefighters (mean±SD r<sub>AiDA</sub> 0.301±0.024 mm; mean±SD R<sub>0</sub> 0.336±0.116 arbitrary units) and controls (mean±SD r<sub>AiDA</sub> 0.276±0.044 mm; mean±SD R<sub>0</sub> 0.5760.168 arbitrary units), p=0.03 and p&lt;0.001, respectively. Higher forced vital capacity was found in firefighters (mean 101% of predicted) than in controls (mean 93% of predicted; p=0.03). No significant differences were found with regard to either the ratio between forced expiratory volume in 1 s and forced vital capacity or forced expiratory volume in 1 s. The majority of firefighters had diffusing capacity of the lung for carbon monoxide, oscillometry and single-breath nitrogen washout values within the normal ranges. Conclusion AiDA parameters can provide information on early pulmonary peripheral changes that may not be seen with standard techniques used in screening of pulmonary function.</p>}},
  author       = {{Kisiel, Marta A. and Cai, Gui Hong and Sjögren, Madeleine Petersson and Löndahl, Jakob and Jakobsson, Jonas and Wollmer, Per and Malinovschi, Andrei and Svartengren, Magnus}},
  issn         = {{2312-0541}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERJ open research}},
  title        = {{Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters}},
  url          = {{http://dx.doi.org/10.1183/23120541.00504-2022}},
  doi          = {{10.1183/23120541.00504-2022}},
  volume       = {{9}},
  year         = {{2023}},
}