Advanced

Validity and Responsiveness of At-Home Touch Screen Assessments in Advanced Parkinson's Disease

Memedi, Mevludin; Nyholm, Dag; Johansson, Anders; Palhagen, Sven; Willows, Thomas; Widner, Håkan LU ; Linder, Jan and Westin, Jerker (2015) In IEEE Journal of Biomedical and Health Informatics 19(6). p.1829-1834
Abstract
The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson's disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient... (More)
The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson's disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on unified PD rating scale (UPDRS) and 39-item PD questionnaire (PDQ-39) scales. In LCIG-naive patients, the mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non naive patients, there were no significant changes in the mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS, respectively. The trends of the test scores were similar to the trends of clinical rating scores but the dropout rate was high. Correlations betweenOTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
telemedicine., monitoring, remote, disease (PD), Parkinson's, levodopa infusion, Home assessment
in
IEEE Journal of Biomedical and Health Informatics
volume
19
issue
6
pages
1829 - 1834
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000364857000007
  • scopus:84959209820
ISSN
2168-2194
DOI
10.1109/JBHI.2015.2468088
language
English
LU publication?
yes
id
64b81fb9-2bad-4217-a2c9-bbbc345c835c (old id 8370712)
date added to LUP
2016-01-04 07:05:45
date last changed
2017-10-01 03:24:45
@article{64b81fb9-2bad-4217-a2c9-bbbc345c835c,
  abstract     = {The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson's disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on unified PD rating scale (UPDRS) and 39-item PD questionnaire (PDQ-39) scales. In LCIG-naive patients, the mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non naive patients, there were no significant changes in the mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS, respectively. The trends of the test scores were similar to the trends of clinical rating scores but the dropout rate was high. Correlations betweenOTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.},
  author       = {Memedi, Mevludin and Nyholm, Dag and Johansson, Anders and Palhagen, Sven and Willows, Thomas and Widner, Håkan and Linder, Jan and Westin, Jerker},
  issn         = {2168-2194},
  keyword      = {telemedicine.,monitoring,remote,disease (PD),Parkinson's,levodopa infusion,Home assessment},
  language     = {eng},
  number       = {6},
  pages        = {1829--1834},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Journal of Biomedical and Health Informatics},
  title        = {Validity and Responsiveness of At-Home Touch Screen Assessments in Advanced Parkinson's Disease},
  url          = {http://dx.doi.org/10.1109/JBHI.2015.2468088},
  volume       = {19},
  year         = {2015},
}