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Left and Right Atrial Contribution to the P-wave in Realistic Computational Models

Loewe, Axel; Krueger, Martin W.; Platonov, Pyotr LU ; Holmqvist, Fredrik LU ; Doessel, Olaf and Seemann, Gunnar (2015) 8th International Conference on Functional Imaging and Modeling of the Heart(FIMH) In Lecture Notes in Computer Science 9126. p.439-447
Abstract
ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to simulate P-waves originating from the left atrium (LA) and the right atrium (RA) separately in two realistic models. LA contribution to the P-wave integral was limited to 30% or less. Around 20% could be attributed to the first third of the P-wave which reflected almost only RA depolarization. Both atria contributed to the second and last third... (More)
ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to simulate P-waves originating from the left atrium (LA) and the right atrium (RA) separately in two realistic models. LA contribution to the P-wave integral was limited to 30% or less. Around 20% could be attributed to the first third of the P-wave which reflected almost only RA depolarization. Both atria contributed to the second and last third with RA contribution being about twice as large as LA contribution. Our results foster the comprehension of the difficulties related to ECG-based LA assessment. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
atrial enlargement, Left, Mathematical modeling, P-wave, Electrocardiogram, Atrial modeling
in
Lecture Notes in Computer Science
volume
9126
pages
439 - 447
publisher
Springer
conference name
8th International Conference on Functional Imaging and Modeling of the Heart(FIMH)
external identifiers
  • wos:000364538500050
  • scopus:84949936930
ISSN
0302-9743
1611-3349
DOI
10.1007/978-3-319-20309-6_50
language
English
LU publication?
yes
id
7d60b886-8dcc-4b04-a6c0-f31339fee203 (old id 8386446)
date added to LUP
2015-12-22 09:31:55
date last changed
2017-09-10 03:01:53
@inproceedings{7d60b886-8dcc-4b04-a6c0-f31339fee203,
  abstract     = {ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to simulate P-waves originating from the left atrium (LA) and the right atrium (RA) separately in two realistic models. LA contribution to the P-wave integral was limited to 30% or less. Around 20% could be attributed to the first third of the P-wave which reflected almost only RA depolarization. Both atria contributed to the second and last third with RA contribution being about twice as large as LA contribution. Our results foster the comprehension of the difficulties related to ECG-based LA assessment.},
  author       = {Loewe, Axel and Krueger, Martin W. and Platonov, Pyotr and Holmqvist, Fredrik and Doessel, Olaf and Seemann, Gunnar},
  booktitle    = {Lecture Notes in Computer Science},
  issn         = {0302-9743},
  keyword      = {atrial enlargement,Left,Mathematical modeling,P-wave,Electrocardiogram,Atrial modeling},
  language     = {eng},
  pages        = {439--447},
  publisher    = {Springer},
  title        = {Left and Right Atrial Contribution to the P-wave in Realistic Computational Models},
  url          = {http://dx.doi.org/10.1007/978-3-319-20309-6_50},
  volume       = {9126},
  year         = {2015},
}