Advanced

The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype

Cortez, Daniel LU ; Svensson, Anneli; Carlson, Jonas LU ; Graw, Sharon; Sharma, Nandita; Brun, Francesca; Spezzacatene, Anita; Mestroni, Luisa and Platonov, Pyotr G. LU (2018) In Journal of Electrocardiology 51(6). p.1003-1008
Abstract

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years,... (More)

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years, 65.2%male). Only the S-wave angle differentiated −ECG ARVD/C patients from controls (<0.001) with AU the ROC curve of 0.77 (95%CI 0.53 to 0.71) and odds ratio of 28.3 (95%CI 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arrhythmogenic right ventricular cardiomyopathy, Cascade screening, ECG, S-wave angle
in
Journal of Electrocardiology
volume
51
issue
6
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85052642550
ISSN
0022-0736
DOI
10.1016/j.jelectrocard.2018.08.009
language
English
LU publication?
yes
id
83e951eb-95da-4b78-b958-6f0269d15846
date added to LUP
2018-09-25 08:12:13
date last changed
2018-11-21 21:41:45
@article{83e951eb-95da-4b78-b958-6f0269d15846,
  abstract     = {<p>Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years, 65.2%male). Only the S-wave angle differentiated −ECG ARVD/C patients from controls (&lt;0.001) with AU the ROC curve of 0.77 (95%CI 0.53 to 0.71) and odds ratio of 28.3 (95%CI 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria.</p>},
  author       = {Cortez, Daniel and Svensson, Anneli and Carlson, Jonas and Graw, Sharon and Sharma, Nandita and Brun, Francesca and Spezzacatene, Anita and Mestroni, Luisa and Platonov, Pyotr G.},
  issn         = {0022-0736},
  keyword      = {Arrhythmogenic right ventricular cardiomyopathy,Cascade screening,ECG,S-wave angle},
  language     = {eng},
  month        = {11},
  number       = {6},
  pages        = {1003--1008},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2018.08.009},
  volume       = {51},
  year         = {2018},
}