The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype
(2018) In Journal of Electrocardiology 51(6). p.1003-1008- Abstract
Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years,... (More)
Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years, 65.2%male). Only the S-wave angle differentiated −ECG ARVD/C patients from controls (<0.001) with AU the ROC curve of 0.77 (95%CI 0.53 to 0.71) and odds ratio of 28.3 (95%CI 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria.
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- author
- Cortez, Daniel LU ; Svensson, Anneli ; Carlson, Jonas LU ; Graw, Sharon ; Sharma, Nandita ; Brun, Francesca ; Spezzacatene, Anita ; Mestroni, Luisa and Platonov, Pyotr G. LU
- organization
- publishing date
- 2018-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arrhythmogenic right ventricular cardiomyopathy, Cascade screening, ECG, S-wave angle
- in
- Journal of Electrocardiology
- volume
- 51
- issue
- 6
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:30497719
- scopus:85052642550
- ISSN
- 0022-0736
- DOI
- 10.1016/j.jelectrocard.2018.08.009
- language
- English
- LU publication?
- yes
- id
- 83e951eb-95da-4b78-b958-6f0269d15846
- date added to LUP
- 2018-09-25 08:12:13
- date last changed
- 2024-06-24 19:39:46
@article{83e951eb-95da-4b78-b958-6f0269d15846, abstract = {{<p>Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years, 65.2%male). Only the S-wave angle differentiated −ECG ARVD/C patients from controls (<0.001) with AU the ROC curve of 0.77 (95%CI 0.53 to 0.71) and odds ratio of 28.3 (95%CI 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria.</p>}}, author = {{Cortez, Daniel and Svensson, Anneli and Carlson, Jonas and Graw, Sharon and Sharma, Nandita and Brun, Francesca and Spezzacatene, Anita and Mestroni, Luisa and Platonov, Pyotr G.}}, issn = {{0022-0736}}, keywords = {{Arrhythmogenic right ventricular cardiomyopathy; Cascade screening; ECG; S-wave angle}}, language = {{eng}}, month = {{11}}, number = {{6}}, pages = {{1003--1008}}, publisher = {{Elsevier}}, series = {{Journal of Electrocardiology}}, title = {{The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype}}, url = {{http://dx.doi.org/10.1016/j.jelectrocard.2018.08.009}}, doi = {{10.1016/j.jelectrocard.2018.08.009}}, volume = {{51}}, year = {{2018}}, }