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RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3.

Api, A M; Belsito, D; Bhatia, S; Bruze, Magnus LU ; Calow, P; Dagli, M L; Dekant, W; Fryer, A D; Kromidas, L and La Cava, S, et al. (2016) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S. p.1-10
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.
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published
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in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
97S
pages
1 - 10
publisher
Elsevier
external identifiers
  • pmid:26702988
  • scopus:84997447780
ISSN
1873-6351
DOI
10.1016/j.fct.2015.12.010
language
English
LU publication?
yes
id
74589498-1e68-4ebc-bc7e-1d6bf3e3f7fe (old id 8503639)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26702988?dopt=Abstract
date added to LUP
2016-01-06 13:35:49
date last changed
2017-03-30 11:39:41
@article{74589498-1e68-4ebc-bc7e-1d6bf3e3f7fe,
  abstract     = {The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.},
  author       = {Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and La Cava, S and Lalko, J F and Lapczynski, A and Liebler, D C and Miyachi, Y and Politano, V T and Ritacco, G and Salvito, D and Schultz, T W and Shen, J and Sipes, I G and Wall, B and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  pages        = {1--10},
  publisher    = {Elsevier},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3.},
  url          = {http://dx.doi.org/10.1016/j.fct.2015.12.010},
  volume       = {97S},
  year         = {2016},
}