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Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.

Erlandsson, Lena LU ; Nääv, Åsa LU ; Hennessy, Annemarie; Vaiman, Daniel; Gram, Magnus LU ; Åkerström, Bo LU and Hansson, Stefan LU (2016) In American Journal of Reproductive Immunology 75(3). p.402-410
Abstract
Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four... (More)
Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
American Journal of Reproductive Immunology
volume
75
issue
3
pages
402 - 410
publisher
Wiley-Blackwell
external identifiers
  • pmid:26685057
  • scopus:84951775525
  • wos:000370158300023
ISSN
1600-0897
DOI
10.1111/aji.12460
language
English
LU publication?
yes
id
3192842c-c1ec-4126-b229-3bae300f770f (old id 8504174)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26685057?dopt=Abstract
date added to LUP
2016-01-06 11:25:57
date last changed
2017-05-16 00:01:00
@article{3192842c-c1ec-4126-b229-3bae300f770f,
  abstract     = {Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.},
  author       = {Erlandsson, Lena and Nääv, Åsa and Hennessy, Annemarie and Vaiman, Daniel and Gram, Magnus and Åkerström, Bo and Hansson, Stefan},
  issn         = {1600-0897},
  language     = {eng},
  number       = {3},
  pages        = {402--410},
  publisher    = {Wiley-Blackwell},
  series       = {American Journal of Reproductive Immunology},
  title        = {Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.},
  url          = {http://dx.doi.org/10.1111/aji.12460},
  volume       = {75},
  year         = {2016},
}