Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor.
Johansson, Fredrik LU ; Carlsson, Hannes A E ; Rasmussen, Anders LU
; Yeo, Christopher H
and Hesslow, Germund
LU
(2015)
In Cell Reports
13(9).
p.1741-1746
- Abstract
- Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence... (More)
- Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence of a distinct learning mechanism, different from changes in synaptic strength. They also demonstrate in vivo post-synaptic inhibition mediated by glutamate and show that the mGlu7 receptor is involved in activating intrinsic temporal memory. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8505191
- author
- Johansson, Fredrik
LU
; Carlsson, Hannes A E
; Rasmussen, Anders
LU
; Yeo, Christopher H
and Hesslow, Germund
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Reports
- volume
- 13
- issue
- 9
- pages
- 1741 - 1746
- publisher
- Cell Press
- external identifiers
-
- pmid:26655894
- wos:000366047000002
- scopus:84947591422
- pmid:26655894
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2015.10.047
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- 06f98347-a4fa-4701-aca0-98722fa8cc90 (old id 8505191)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26655894?dopt=Abstract
- date added to LUP
- 2016-04-01 14:50:27
- date last changed
- 2022-03-22 02:13:45
@article{06f98347-a4fa-4701-aca0-98722fa8cc90,
abstract = {{Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence of a distinct learning mechanism, different from changes in synaptic strength. They also demonstrate in vivo post-synaptic inhibition mediated by glutamate and show that the mGlu7 receptor is involved in activating intrinsic temporal memory.}},
author = {{Johansson, Fredrik and Carlsson, Hannes A E and Rasmussen, Anders and Yeo, Christopher H and Hesslow, Germund}},
issn = {{2211-1247}},
language = {{eng}},
number = {{9}},
pages = {{1741--1746}},
publisher = {{Cell Press}},
series = {{Cell Reports}},
title = {{Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor.}},
url = {{http://dx.doi.org/10.1016/j.celrep.2015.10.047}},
doi = {{10.1016/j.celrep.2015.10.047}},
volume = {{13}},
year = {{2015}},
}