Prenatal current-use pesticide exposure and children's neurodevelopment at one year of age in the Infants' Environmental Health (ISA) birth cohort, Costa Rica
Conejo-Bolaños, L. Diego ; Mora, Ana M. ; Hernández-Bonilla, David ; Cano, Juan Camilo ; Menezes-Filho, José A. ; Eskenazi, Brenda ; Lindh, Christian H. LU
and van Wendel de Joode, Berna
(2024)
In Environmental Research
249.
- Abstract
Background: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides. Objective: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants’ Environmental Health (ISA) birth cohort. Methods: To determine prenatal pesticide exposure, we measured biomarkers of pyrimethanil, chlorpyrifos, synthetic pyrethroids, and 2,4-D in urine samples among 355 women, 1–3 times during pregnancy. One-year post-partum, we evaluated children's neurodevelopment with the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III). We assessed associations... (More)
Background: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides. Objective: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants’ Environmental Health (ISA) birth cohort. Methods: To determine prenatal pesticide exposure, we measured biomarkers of pyrimethanil, chlorpyrifos, synthetic pyrethroids, and 2,4-D in urine samples among 355 women, 1–3 times during pregnancy. One-year post-partum, we evaluated children's neurodevelopment with the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III). We assessed associations between exposures and neurodevelopmental outcomes (composite and z-scores) using single-chemical linear regression models adjusted for possible confounders (maternal education, parity, sex, gestational age at birth, child age, HOME-score, location of assessment, biomarkers of mancozeb), and studied effect-modification by sex. We evaluated non-linear associations of multiple pesticide exposures with Bayesian kernel machine regression (BKMR). Results: We found higher prenatal urinary 2,4-D concentrations were associated with lower language (βper ten-fold increase = −2.0, 95 % confidence interval (CI) = −3.5, −0.5) and motor (βper ten-fold increase = −2.2, 95 %CI = −4.2, −0.1) composite scores among all children. Also, higher chlorpyrifos exposure [measured as urinary 3,5,6-trichloro-2-pyridinol (TCPy)] was associated with lower cognitive composite scores (βper ten-fold increase = −1.9, 95 %CI = −4.7, 0.8), and lower motor composite scores among boys (βper ten-fold increase = −3.8, 95 % CI = −7.7, 0.1) but not girls (βper ten-fold increase = 2.3, 95 %CI = −1.6, 6.3, pINT = 0.11). Finally, higher pyrimethanil was associated with lower language abilities among girls, but not boys. Pyrethroid metabolite concentrations did not explain variability in BSID-III composite scores. Associations were similar for BSID-III z-scores, and we found no evidence for non-linear associations or mixture effects. Discussion: Prenatal exposure to common-use pesticides may affect children's neurodevelopment at 1-year of age, some effects may be sex-specific.
(Less)
- author
- Conejo-Bolaños, L. Diego
; Mora, Ana M.
; Hernández-Bonilla, David
; Cano, Juan Camilo
; Menezes-Filho, José A.
; Eskenazi, Brenda
; Lindh, Christian H.
LU
and van Wendel de Joode, Berna
- organization
- publishing date
- 2024-05-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 2,4-D, Chlorpyrifos, Epidemiology, In-utero, Pesticides, Pyrimethanil
- in
- Environmental Research
- volume
- 249
- article number
- 118222
- publisher
- Elsevier
- external identifiers
-
- pmid:38272290
- scopus:85184803145
- ISSN
- 0013-9351
- DOI
- 10.1016/j.envres.2024.118222
- language
- English
- LU publication?
- yes
- id
- 8540f8ac-88e8-4c09-821a-17b4eac1dbab
- date added to LUP
- 2024-03-12 14:50:31
- date last changed
- 2024-04-23 19:26:39
@article{8540f8ac-88e8-4c09-821a-17b4eac1dbab,
abstract = {{<p>Background: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides. Objective: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants’ Environmental Health (ISA) birth cohort. Methods: To determine prenatal pesticide exposure, we measured biomarkers of pyrimethanil, chlorpyrifos, synthetic pyrethroids, and 2,4-D in urine samples among 355 women, 1–3 times during pregnancy. One-year post-partum, we evaluated children's neurodevelopment with the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III). We assessed associations between exposures and neurodevelopmental outcomes (composite and z-scores) using single-chemical linear regression models adjusted for possible confounders (maternal education, parity, sex, gestational age at birth, child age, HOME-score, location of assessment, biomarkers of mancozeb), and studied effect-modification by sex. We evaluated non-linear associations of multiple pesticide exposures with Bayesian kernel machine regression (BKMR). Results: We found higher prenatal urinary 2,4-D concentrations were associated with lower language (β<sub>per ten-fold increase</sub> = −2.0, 95 % confidence interval (CI) = −3.5, −0.5) and motor (β<sub>per ten-fold increase</sub> = −2.2, 95 %CI = −4.2, −0.1) composite scores among all children. Also, higher chlorpyrifos exposure [measured as urinary 3,5,6-trichloro-2-pyridinol (TCPy)] was associated with lower cognitive composite scores (β<sub>per ten-fold increase</sub> = −1.9, 95 %CI = −4.7, 0.8), and lower motor composite scores among boys (β<sub>per ten-fold increase</sub> = −3.8, 95 % CI = −7.7, 0.1) but not girls (β<sub>per ten-fold increase</sub> = 2.3, 95 %CI = −1.6, 6.3, pINT = 0.11). Finally, higher pyrimethanil was associated with lower language abilities among girls, but not boys. Pyrethroid metabolite concentrations did not explain variability in BSID-III composite scores. Associations were similar for BSID-III z-scores, and we found no evidence for non-linear associations or mixture effects. Discussion: Prenatal exposure to common-use pesticides may affect children's neurodevelopment at 1-year of age, some effects may be sex-specific.</p>}},
author = {{Conejo-Bolaños, L. Diego and Mora, Ana M. and Hernández-Bonilla, David and Cano, Juan Camilo and Menezes-Filho, José A. and Eskenazi, Brenda and Lindh, Christian H. and van Wendel de Joode, Berna}},
issn = {{0013-9351}},
keywords = {{2,4-D; Chlorpyrifos; Epidemiology; In-utero; Pesticides; Pyrimethanil}},
language = {{eng}},
month = {{05}},
publisher = {{Elsevier}},
series = {{Environmental Research}},
title = {{Prenatal current-use pesticide exposure and children's neurodevelopment at one year of age in the Infants' Environmental Health (ISA) birth cohort, Costa Rica}},
url = {{http://dx.doi.org/10.1016/j.envres.2024.118222}},
doi = {{10.1016/j.envres.2024.118222}},
volume = {{249}},
year = {{2024}},
}