Infections are associated with increased risk of giant cell arteritis - a population-based case-control study from Southern Sweden
(2020) In Journal of Rheumatology 47(6).- Abstract
- Objective To investigate the association of infections with the subsequent development of giant cell arteritis (GCA) in a large population-based cohort from a defined geographic area in Sweden.
Methods Patients diagnosed with biopsy-confirmed GCA between 2000 and 2016 were identified through the database of the Department of Pathology in Skåne, the southernmost region of Sweden. For each GCA case, 10 controls matched for age, sex, and area of residence were randomly selected from the general population. Using the Skåne Healthcare Register, we identified all infection events prior to the date of GCA diagnosis and index date of controls. With infection as exposure, a conditional logistic regression model was employed to estimate the... (More) - Objective To investigate the association of infections with the subsequent development of giant cell arteritis (GCA) in a large population-based cohort from a defined geographic area in Sweden.
Methods Patients diagnosed with biopsy-confirmed GCA between 2000 and 2016 were identified through the database of the Department of Pathology in Skåne, the southernmost region of Sweden. For each GCA case, 10 controls matched for age, sex, and area of residence were randomly selected from the general population. Using the Skåne Healthcare Register, we identified all infection events prior to the date of GCA diagnosis and index date of controls. With infection as exposure, a conditional logistic regression model was employed to estimate the odds ratio (OR) for developing GCA. The types of infections contracted nearest in time to the GCA diagnosis/index date were identified.
Results A total of 1005 patients with biopsy-confirmed GCA (71% female) and 10 050 controls were included in the analysis. Infections were more common among patients subsequently diagnosed with GCA compared to controls [51% vs. 41%, OR 1.78; 95% confidence interval (CI) 1.53–2.07]. Acute upper respiratory tract infection (OR 1.77; 95 %. CI 1.47–2.14), influenza and pneumonia (OR 1.72; 95 % CI 1.35–2.19), and unspecified infections (OR 5.35; 95 % CI 3.46–8.28) were associated with GCA. Neither skin nor gastrointestinal infections showed a correlation.
Conclusion Infections, especially those of the respiratory tract, were associated with subsequent development of biopsy-confirmed GCA. Our findings support the hypothesis that a range of infections may trigger GCA. (Less)
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https://lup.lub.lu.se/record/855252db-d82c-470a-a117-2dc3f7ac549b
- author
- Stamatis, Pavlos
LU
; Turkiewicz, Aleksandra LU ; Englund, Martin LU
; Jönsson, Göran LU ; Nilsson, Jan-Åke LU ; Turesson, Carl LU and Mohammad, Aladdin LU
- organization
-
- Rheumatology
- Lund OsteoArthritis Division - Clinical Epidemiology Unit (research group)
- Orthopaedics (Lund)
- EpiHealth: Epidemiology for Health
- Infection Medicine (BMC)
- Orthopedics (research group)
- Internal Medicine - Epidemiology (research group)
- Lund Vasculitis Epidemiology Research Group (research group)
- Autoimmunity and kidney diseases (research group)
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Rheumatology
- volume
- 47
- issue
- 6
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- pmid:32414956
- scopus:85100181670
- ISSN
- 0315-162X
- DOI
- 10.3899/jrheum.200211
- language
- English
- LU publication?
- yes
- id
- 855252db-d82c-470a-a117-2dc3f7ac549b
- date added to LUP
- 2020-05-31 06:58:57
- date last changed
- 2024-05-29 13:21:11
@article{855252db-d82c-470a-a117-2dc3f7ac549b, abstract = {{Objective To investigate the association of infections with the subsequent development of giant cell arteritis (GCA) in a large population-based cohort from a defined geographic area in Sweden.<br/><br/>Methods Patients diagnosed with biopsy-confirmed GCA between 2000 and 2016 were identified through the database of the Department of Pathology in Skåne, the southernmost region of Sweden. For each GCA case, 10 controls matched for age, sex, and area of residence were randomly selected from the general population. Using the Skåne Healthcare Register, we identified all infection events prior to the date of GCA diagnosis and index date of controls. With infection as exposure, a conditional logistic regression model was employed to estimate the odds ratio (OR) for developing GCA. The types of infections contracted nearest in time to the GCA diagnosis/index date were identified.<br/><br/>Results A total of 1005 patients with biopsy-confirmed GCA (71% female) and 10 050 controls were included in the analysis. Infections were more common among patients subsequently diagnosed with GCA compared to controls [51% vs. 41%, OR 1.78; 95% confidence interval (CI) 1.53–2.07]. Acute upper respiratory tract infection (OR 1.77; 95 %. CI 1.47–2.14), influenza and pneumonia (OR 1.72; 95 % CI 1.35–2.19), and unspecified infections (OR 5.35; 95 % CI 3.46–8.28) were associated with GCA. Neither skin nor gastrointestinal infections showed a correlation.<br/><br/>Conclusion Infections, especially those of the respiratory tract, were associated with subsequent development of biopsy-confirmed GCA. Our findings support the hypothesis that a range of infections may trigger GCA.}}, author = {{Stamatis, Pavlos and Turkiewicz, Aleksandra and Englund, Martin and Jönsson, Göran and Nilsson, Jan-Åke and Turesson, Carl and Mohammad, Aladdin}}, issn = {{0315-162X}}, language = {{eng}}, number = {{6}}, publisher = {{Journal of Rheumatology Publishing Company Limited}}, series = {{Journal of Rheumatology}}, title = {{Infections are associated with increased risk of giant cell arteritis - a population-based case-control study from Southern Sweden}}, url = {{http://dx.doi.org/10.3899/jrheum.200211}}, doi = {{10.3899/jrheum.200211}}, volume = {{47}}, year = {{2020}}, }