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In vivo magnetomotive ultrasound imaging of rat lymph nodes - a pilot study

Evertsson, Maria LU ; Cinthio, Magnus LU ; Kjellman, Pontus LU ; Fredriksson, Sarah; Andersson, Roger LU ; Toftevall, Hanna; Persson, Hans W LU and Jansson, Tomas LU (2015) IEEE International Ultrasonics Symposium (IUS), 2015 In 2015 IEEE International Ultrasonics Symposium (IUS)
Abstract
The drive to gain a better understanding of how diseases arise and how to provide ever-earlier detection are some of the key factors for the development of molecular imaging. Compared to other imaging modalities ultrasound has not received the same attention for molecular imaging mainly due to its limited contrast resolution, together with contrast agents confined to the intravascular space. To overcome these issues, new nano-sized contrast agents and new ultrasound imaging techniques e.g. photo acoustic imaging, have been developed. Another such imaging technique under development is magnetomotive ultrasound imaging (MMUS). We have previously developed a frequency and phase tracking algorithm which is able to detect superparamagnetic iron... (More)
The drive to gain a better understanding of how diseases arise and how to provide ever-earlier detection are some of the key factors for the development of molecular imaging. Compared to other imaging modalities ultrasound has not received the same attention for molecular imaging mainly due to its limited contrast resolution, together with contrast agents confined to the intravascular space. To overcome these issues, new nano-sized contrast agents and new ultrasound imaging techniques e.g. photo acoustic imaging, have been developed. Another such imaging technique under development is magnetomotive ultrasound imaging (MMUS). We have previously developed a frequency and phase tracking algorithm which is able to detect superparamagnetic iron oxide nanoparticles (SPIO NPs) using MMUS, where our suggested first clinical application is to detect sentinel lymph nodes (SLNs) in breast cancer surgery. Recently we have shown detection of SPIO laden rat SLNs in situ. Here we present the feasibility of in vivo detection of SLNs in rats. The algorithm clearly pinpoints the NP laden SLN, even in presence of significant artefactual tissue movement. The magnetomotive displacement increased when a higher voltage was applied on the coil creating the magnetic field (e.g. 56.6% increasing the voltage from 20V to 50V). An uneven concentration distribution of NPs in the SLN was found. The maximum magnetomotive displacement difference between two different cross sections in one SLN was 9.76 times. The study also showed that for a higher concentration of NPs a lower magnetic coil excitation voltage could be used in order to create a magnetomotive displacement of a certain magnitude. The result from this in vivo study shows that the method has potential for future clinical use. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Magnetomotive ultrasound imaging, molecular imaging sentinel lymph, nodes, in vivo imaging, contrast agents, multimodal imaging
in
2015 IEEE International Ultrasonics Symposium (IUS)
pages
4 pages
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
IEEE International Ultrasonics Symposium (IUS), 2015
external identifiers
  • wos:000366045700017
  • scopus:84961992398
ISSN
1948-5719
DOI
10.1109/ULTSYM.2015.0261
language
English
LU publication?
yes
id
3986f809-ee9b-47cc-9a02-c1db47482d51 (old id 8560030)
date added to LUP
2016-01-26 12:02:33
date last changed
2017-11-16 13:00:50
@inproceedings{3986f809-ee9b-47cc-9a02-c1db47482d51,
  abstract     = {The drive to gain a better understanding of how diseases arise and how to provide ever-earlier detection are some of the key factors for the development of molecular imaging. Compared to other imaging modalities ultrasound has not received the same attention for molecular imaging mainly due to its limited contrast resolution, together with contrast agents confined to the intravascular space. To overcome these issues, new nano-sized contrast agents and new ultrasound imaging techniques e.g. photo acoustic imaging, have been developed. Another such imaging technique under development is magnetomotive ultrasound imaging (MMUS). We have previously developed a frequency and phase tracking algorithm which is able to detect superparamagnetic iron oxide nanoparticles (SPIO NPs) using MMUS, where our suggested first clinical application is to detect sentinel lymph nodes (SLNs) in breast cancer surgery. Recently we have shown detection of SPIO laden rat SLNs in situ. Here we present the feasibility of in vivo detection of SLNs in rats. The algorithm clearly pinpoints the NP laden SLN, even in presence of significant artefactual tissue movement. The magnetomotive displacement increased when a higher voltage was applied on the coil creating the magnetic field (e.g. 56.6% increasing the voltage from 20V to 50V). An uneven concentration distribution of NPs in the SLN was found. The maximum magnetomotive displacement difference between two different cross sections in one SLN was 9.76 times. The study also showed that for a higher concentration of NPs a lower magnetic coil excitation voltage could be used in order to create a magnetomotive displacement of a certain magnitude. The result from this in vivo study shows that the method has potential for future clinical use.},
  author       = {Evertsson, Maria and Cinthio, Magnus and Kjellman, Pontus and Fredriksson, Sarah and Andersson, Roger and Toftevall, Hanna and Persson, Hans W and Jansson, Tomas},
  booktitle    = {2015 IEEE International Ultrasonics Symposium (IUS)},
  issn         = {1948-5719},
  keyword      = {Magnetomotive ultrasound imaging,molecular imaging sentinel lymph,nodes,in vivo imaging,contrast agents,multimodal imaging},
  language     = {eng},
  pages        = {4},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  title        = {In vivo magnetomotive ultrasound imaging of rat lymph nodes - a pilot study},
  url          = {http://dx.doi.org/10.1109/ULTSYM.2015.0261},
  year         = {2015},
}