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RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1.

Api, A M; Belsito, D; Bhatia, S; Bruze, Magnus LU ; Calow, P; Dagli, M L; Dekant, W; Fryer, A D; Kromidas, L and La Cava, S, et al. (2016) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97. p.49-56
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 37.5 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in mice resulted in a MOE of 5769 while considering 38.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
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published
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in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
97
pages
49 - 56
publisher
Elsevier
external identifiers
  • pmid:26723296
  • scopus:84953394755
ISSN
1873-6351
DOI
10.1016/j.fct.2015.12.021
language
English
LU publication?
yes
id
3911201c-afe0-4836-a2f4-3f2aa01c0fbb (old id 8593420)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26723296?dopt=Abstract
date added to LUP
2016-02-09 17:56:06
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2017-04-25 08:23:42
@article{3911201c-afe0-4836-a2f4-3f2aa01c0fbb,
  abstract     = {The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 37.5 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in mice resulted in a MOE of 5769 while considering 38.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.},
  author       = {Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and La Cava, S and Lalko, J F and Lapczynski, A and Liebler, D C and Miyachi, Y and Politano, V T and Ritacco, G and Salvito, D and Schultz, T W and Shen, J and Sipes, I G and Wall, B and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  pages        = {49--56},
  publisher    = {Elsevier},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1.},
  url          = {http://dx.doi.org/10.1016/j.fct.2015.12.021},
  volume       = {97},
  year         = {2016},
}