Mechanisms for motor timing in the cerebellar cortex
(2016) In Current Opinion in Behavioral Sciences 8. p.53-59- Abstract
- In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8593658
- author
- Johansson, Fredrik LU ; Hesslow, Germund LU and Medina, Javier
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Behavioral Sciences
- volume
- 8
- pages
- 53 - 59
- publisher
- Elsevier
- external identifiers
-
- scopus:84957872448
- pmid:26949723
- pmid:26949723
- wos:000395323100010
- ISSN
- 2352-1554
- DOI
- 10.1016/j.cobeha.2016.01.013
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- 9ff945f4-7b26-4c5b-a1bf-371efe2f06f6 (old id 8593658)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26949723
- date added to LUP
- 2016-04-01 13:28:41
- date last changed
- 2023-01-03 23:08:04
@article{9ff945f4-7b26-4c5b-a1bf-371efe2f06f6,
abstract = {{In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).}},
author = {{Johansson, Fredrik and Hesslow, Germund and Medina, Javier}},
issn = {{2352-1554}},
language = {{eng}},
pages = {{53--59}},
publisher = {{Elsevier}},
series = {{Current Opinion in Behavioral Sciences}},
title = {{Mechanisms for motor timing in the cerebellar cortex}},
url = {{http://dx.doi.org/10.1016/j.cobeha.2016.01.013}},
doi = {{10.1016/j.cobeha.2016.01.013}},
volume = {{8}},
year = {{2016}},
}