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Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes

Dwibedi, Chinmay ; Mellergård, Emelia LU ; Gyllensten, Amaru Cuba ; Nilsson, Kristoffer ; Axelsson, Annika S. ; Bäckman, Malin LU ; Sahlgren, Magnus ; Friend, Stephen H. ; Persson, Sofie LU and Franzén, Stefan , et al. (2022) In npj Digital Medicine 5(1).
Abstract

The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in 370 patients with type 2 diabetes (ClinicalTrials.gov identifier: NCT04691973). Users of the tool had reduced blood glucose, both compared with randomized and matched controls (involving 158 and 204 users, respectively), as well as improved systolic blood pressure, body weight and insulin resistance. The improvement was sustained during the entire follow-up (average 730 days). A pathophysiological subgroup of obese insulin-resistant... (More)

The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in 370 patients with type 2 diabetes (ClinicalTrials.gov identifier: NCT04691973). Users of the tool had reduced blood glucose, both compared with randomized and matched controls (involving 158 and 204 users, respectively), as well as improved systolic blood pressure, body weight and insulin resistance. The improvement was sustained during the entire follow-up (average 730 days). A pathophysiological subgroup of obese insulin-resistant individuals had a pronounced glycemic response, enabling identification of those who would benefit in particular from lifestyle treatment. Natural language processing showed that the metabolic improvement was coupled with the self-reflective element of the tool. The treatment is cost-saving because of improved risk factor control for cardiovascular complications. The findings open an avenue for self-managed lifestyle treatment with long-term metabolic efficacy that is cost-saving and can reach large numbers of people.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ANDIS, diabetes
in
npj Digital Medicine
volume
5
issue
1
article number
60
publisher
Nature Publishing Group
external identifiers
  • scopus:85129954140
  • pmid:35545657
ISSN
2398-6352
DOI
10.1038/s41746-022-00606-9
language
English
LU publication?
yes
id
859af74e-f631-45e1-8ca0-c9f14dbe2b55
date added to LUP
2022-12-29 11:18:32
date last changed
2024-06-15 01:16:08
@article{859af74e-f631-45e1-8ca0-c9f14dbe2b55,
  abstract     = {{<p>The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in 370 patients with type 2 diabetes (ClinicalTrials.gov identifier: NCT04691973). Users of the tool had reduced blood glucose, both compared with randomized and matched controls (involving 158 and 204 users, respectively), as well as improved systolic blood pressure, body weight and insulin resistance. The improvement was sustained during the entire follow-up (average 730 days). A pathophysiological subgroup of obese insulin-resistant individuals had a pronounced glycemic response, enabling identification of those who would benefit in particular from lifestyle treatment. Natural language processing showed that the metabolic improvement was coupled with the self-reflective element of the tool. The treatment is cost-saving because of improved risk factor control for cardiovascular complications. The findings open an avenue for self-managed lifestyle treatment with long-term metabolic efficacy that is cost-saving and can reach large numbers of people.</p>}},
  author       = {{Dwibedi, Chinmay and Mellergård, Emelia and Gyllensten, Amaru Cuba and Nilsson, Kristoffer and Axelsson, Annika S. and Bäckman, Malin and Sahlgren, Magnus and Friend, Stephen H. and Persson, Sofie and Franzén, Stefan and Abrahamsson, Birgitta and Carlsson, Katarina Steen and Rosengren, Anders H.}},
  issn         = {{2398-6352}},
  keywords     = {{ANDIS; diabetes}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{npj Digital Medicine}},
  title        = {{Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes}},
  url          = {{http://dx.doi.org/10.1038/s41746-022-00606-9}},
  doi          = {{10.1038/s41746-022-00606-9}},
  volume       = {{5}},
  year         = {{2022}},
}