The importance of food for endotoxemia and an inflammatory response
(2021) In International Journal of Molecular Sciences 22(17).- Abstract
Bacterial endotoxin is a potent inflammatory antigen abundant in the human intestine. Endotoxins circulate in the blood at low concentrations in all healthy individuals. Elevated levels of circulatory endotoxins may cause inflammation with the development of chronic disease, either affecting metabolism, neurological disease, or resistance to viral and bacterial infections. The most important endotoxin is LPS, being a superantigen. In this narrative review, the effect of various food components to postprandially elevate circulating LPS and inflammatory markers is described. There is evidence that the intake of food enriched in fat, in particular saturated fat, may elevate LPS and pro-inflammatory markers. This occurs in both... (More)
Bacterial endotoxin is a potent inflammatory antigen abundant in the human intestine. Endotoxins circulate in the blood at low concentrations in all healthy individuals. Elevated levels of circulatory endotoxins may cause inflammation with the development of chronic disease, either affecting metabolism, neurological disease, or resistance to viral and bacterial infections. The most important endotoxin is LPS, being a superantigen. In this narrative review, the effect of various food components to postprandially elevate circulating LPS and inflammatory markers is described. There is evidence that the intake of food enriched in fat, in particular saturated fat, may elevate LPS and pro-inflammatory markers. This occurs in both normal-weight and obese subjects. In obese subjects, inflammatory markers are already elevated before meal consumption. The importance of food choice for endotoxemia and inflammatory response is discussed.
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- author
- Erlanson-Albertsson, Charlotte LU and Stenkula, Karin G. LU
- organization
- publishing date
- 2021-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Meat, Obesity, Plant-based diet, Saturated fat, Virus, Western diet
- in
- International Journal of Molecular Sciences
- volume
- 22
- issue
- 17
- article number
- 9562
- publisher
- MDPI AG
- external identifiers
-
- pmid:34502470
- scopus:85114217060
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms22179562
- language
- English
- LU publication?
- yes
- id
- 870fe35e-4ef9-4d99-a82b-5b3144725e8e
- date added to LUP
- 2021-10-04 11:39:44
- date last changed
- 2025-03-09 18:49:49
@article{870fe35e-4ef9-4d99-a82b-5b3144725e8e,
abstract = {{<p>Bacterial endotoxin is a potent inflammatory antigen abundant in the human intestine. Endotoxins circulate in the blood at low concentrations in all healthy individuals. Elevated levels of circulatory endotoxins may cause inflammation with the development of chronic disease, either affecting metabolism, neurological disease, or resistance to viral and bacterial infections. The most important endotoxin is LPS, being a superantigen. In this narrative review, the effect of various food components to postprandially elevate circulating LPS and inflammatory markers is described. There is evidence that the intake of food enriched in fat, in particular saturated fat, may elevate LPS and pro-inflammatory markers. This occurs in both normal-weight and obese subjects. In obese subjects, inflammatory markers are already elevated before meal consumption. The importance of food choice for endotoxemia and inflammatory response is discussed.</p>}},
author = {{Erlanson-Albertsson, Charlotte and Stenkula, Karin G.}},
issn = {{1661-6596}},
keywords = {{Meat; Obesity; Plant-based diet; Saturated fat; Virus; Western diet}},
language = {{eng}},
month = {{09}},
number = {{17}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{The importance of food for endotoxemia and an inflammatory response}},
url = {{http://dx.doi.org/10.3390/ijms22179562}},
doi = {{10.3390/ijms22179562}},
volume = {{22}},
year = {{2021}},
}