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Decreased cord-blood phospholipids in young age at onset type 1 diabetes.

La Torre, Daria LU ; Seppänen-Laakso, Tulikki; Larsson, Helena LU ; Hyötyläinen, Tuulia; Ivarsson, Sten LU ; Lernmark, Åke LU and Oresic, Matej (2013) In Diabetes 62(11). p.3951-3956
Abstract
Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. In this study metabolomics was used to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before eight years of age. The present case-control study of 76 index children diagnosed with type 1 diabetes before eight years of age and 76 healthy controls matched for HLA risk, gender and date of birth as well as mother's age and gestational age revealed that cord-blood phosphatidylcholines and phosphatidylethanolamines were significantly decreased in... (More)
Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. In this study metabolomics was used to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before eight years of age. The present case-control study of 76 index children diagnosed with type 1 diabetes before eight years of age and 76 healthy controls matched for HLA risk, gender and date of birth as well as mother's age and gestational age revealed that cord-blood phosphatidylcholines and phosphatidylethanolamines were significantly decreased in children diagnosed with type 1 diabetes before four years of age. Reduced levels of triglycerides correlated to gestational age in both index and control children and to age at diagnosis only in the index children. Finally, gestational infection during the first trimester was associated with lower cord blood total lysophosphatidylcholines in both index and control children. In conclusion, metabolomics of umbilical cord blood may identify children at increased risk for type 1 diabetes. Low phospholipid levels at birth may represent key mediators of the immune system and contribute in early induction of islet autoimmunity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
62
issue
11
pages
3951 - 3956
publisher
American Diabetes Association Inc.
external identifiers
  • wos:000326290700039
  • pmid:23929934
  • scopus:84890747164
ISSN
1939-327X
DOI
10.2337/db13-0215
language
English
LU publication?
yes
id
8712f93d-0a74-491c-8e9d-50874c5666bc (old id 4005984)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23929934?dopt=Abstract
date added to LUP
2013-09-03 14:59:16
date last changed
2019-03-27 01:24:02
@article{8712f93d-0a74-491c-8e9d-50874c5666bc,
  abstract     = {Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. In this study metabolomics was used to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before eight years of age. The present case-control study of 76 index children diagnosed with type 1 diabetes before eight years of age and 76 healthy controls matched for HLA risk, gender and date of birth as well as mother's age and gestational age revealed that cord-blood phosphatidylcholines and phosphatidylethanolamines were significantly decreased in children diagnosed with type 1 diabetes before four years of age. Reduced levels of triglycerides correlated to gestational age in both index and control children and to age at diagnosis only in the index children. Finally, gestational infection during the first trimester was associated with lower cord blood total lysophosphatidylcholines in both index and control children. In conclusion, metabolomics of umbilical cord blood may identify children at increased risk for type 1 diabetes. Low phospholipid levels at birth may represent key mediators of the immune system and contribute in early induction of islet autoimmunity.},
  author       = {La Torre, Daria and Seppänen-Laakso, Tulikki and Larsson, Helena and Hyötyläinen, Tuulia and Ivarsson, Sten and Lernmark, Åke and Oresic, Matej},
  issn         = {1939-327X},
  language     = {eng},
  number       = {11},
  pages        = {3951--3956},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Decreased cord-blood phospholipids in young age at onset type 1 diabetes.},
  url          = {http://dx.doi.org/10.2337/db13-0215},
  volume       = {62},
  year         = {2013},
}