Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation
(2020) In European Journal of Immunology 50(10). p.1525-1536- Abstract
Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global activation mechanisms. cDC1, the subset of DCs that excel in supporting immunity towards viruses, intracellular bacteria and tumors, express uniquely high levels of the pattern recognition receptor TLR3. Using various murine genetic models, we show here that both, the cDC1 and cDC2 subsets of cDCs are activated and migrate equally well in response... (More)
Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global activation mechanisms. cDC1, the subset of DCs that excel in supporting immunity towards viruses, intracellular bacteria and tumors, express uniquely high levels of the pattern recognition receptor TLR3. Using various murine genetic models, we show here that both, the cDC1 and cDC2 subsets of cDCs are activated and migrate equally well in response to TLR3 stimulation in a cell extrinsic and TNFα dependent manner, but that cDC1 show a unique requirement for type I interferon signaling. Our findings reveal common and differing pathways regulating DC subset migration, offering important insights for the design of DC-based vaccination and therapy approaches. This article is protected by copyright. All rights reserved.
(Less)
- author
- organization
- publishing date
- 2020-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Immunology
- volume
- 50
- issue
- 10
- pages
- 12 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:32383212
- scopus:85085547883
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.201948497
- language
- English
- LU publication?
- yes
- additional info
- This article is protected by copyright. All rights reserved.
- id
- 8745cf21-87c2-4fc1-8173-0ffd0755b417
- date added to LUP
- 2020-05-18 21:20:28
- date last changed
- 2024-07-24 18:32:16
@article{8745cf21-87c2-4fc1-8173-0ffd0755b417, abstract = {{<p>Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global activation mechanisms. cDC1, the subset of DCs that excel in supporting immunity towards viruses, intracellular bacteria and tumors, express uniquely high levels of the pattern recognition receptor TLR3. Using various murine genetic models, we show here that both, the cDC1 and cDC2 subsets of cDCs are activated and migrate equally well in response to TLR3 stimulation in a cell extrinsic and TNFα dependent manner, but that cDC1 show a unique requirement for type I interferon signaling. Our findings reveal common and differing pathways regulating DC subset migration, offering important insights for the design of DC-based vaccination and therapy approaches. This article is protected by copyright. All rights reserved.</p>}}, author = {{López, Agnès Garcias and Bekiaris, Vasileios and Luda, Katarzyna Müller and Hütter, Julia and Ulmert, Isabel and Getachew Muleta, Konjit and Nakawesi, Joy and Kotarsky, Knut and Malissen, Bernard and O'Keeffe, Meredith and Holzmann, Bernhard and Agace, William and Lahl, Katharina}}, issn = {{1521-4141}}, language = {{eng}}, number = {{10}}, pages = {{1525--1536}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Immunology}}, title = {{Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation}}, url = {{http://dx.doi.org/10.1002/eji.201948497}}, doi = {{10.1002/eji.201948497}}, volume = {{50}}, year = {{2020}}, }