Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.
(2008) In Diabetic Medicine: A journal of the British Diabetic Association 25(3). p.303-307- Abstract
- AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4... (More)
- AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1052992
- author
- Glans, Forouzan LU ; Elgzyri, Targ LU ; Shaat, Nael LU ; Lindholm, Eero LU ; Apelqvist, Jan LU and Groop, Leif LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine: A journal of the British Diabetic Association
- volume
- 25
- issue
- 3
- pages
- 303 - 307
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:18307458
- wos:000253609300009
- scopus:40049088818
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2007.02366.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Diabetes and Endocrinology (013241530)
- id
- 879baa84-5280-4c59-a94d-f7909f0cf52f (old id 1052992)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18307458?dopt=Abstract
- date added to LUP
- 2016-04-04 09:18:13
- date last changed
- 2024-04-13 04:47:17
@article{879baa84-5280-4c59-a94d-f7909f0cf52f, abstract = {{AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients.}}, author = {{Glans, Forouzan and Elgzyri, Targ and Shaat, Nael and Lindholm, Eero and Apelqvist, Jan and Groop, Leif}}, issn = {{1464-5491}}, language = {{eng}}, number = {{3}}, pages = {{303--307}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine: A journal of the British Diabetic Association}}, title = {{Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.}}, url = {{http://dx.doi.org/10.1111/j.1464-5491.2007.02366.x}}, doi = {{10.1111/j.1464-5491.2007.02366.x}}, volume = {{25}}, year = {{2008}}, }