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Biomarkers of complement and platelet activation are not correlated with the one or twenty-four hours corrected count increments in prophylactically platelet transfused hematological patients : a prospective cohort study

Åkesson, Alexander LU ; Ljungkvist, Marcus LU ; Martin, Myriam LU ; Blom, Anna M LU orcid ; Klintman, Jenny LU ; Schött, Ulf LU ; Zetterberg, Eva LU and Kander, Thomas LU orcid (2022) In Platelets 33(3). p.350-359
Abstract

Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of platelet concentrates. In this study, the post-transfusion platelet response, as indicated by the corrected count increment at 1 and 24 h after prophylactic platelet transfusions, respectively, was correlated with the 1 h post-transfusion Δconcentration (1 h post-transfusion - pretransfusion) of complement and platelet activation biomarkers. The study was registered as a clinical trial at ClinicalTrials.gov (identifier: NCT02601131) and patients were recruited during inpatient care in the... (More)

Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of platelet concentrates. In this study, the post-transfusion platelet response, as indicated by the corrected count increment at 1 and 24 h after prophylactic platelet transfusions, respectively, was correlated with the 1 h post-transfusion Δconcentration (1 h post-transfusion - pretransfusion) of complement and platelet activation biomarkers. The study was registered as a clinical trial at ClinicalTrials.gov (identifier: NCT02601131) and patients were recruited during inpatient care in the hematological department. Soluble terminal complement complexes, soluble P-selectin and soluble CD40 ligand were analyzed. Confirmed alloimmunized patients were excluded. Included subjects were either given platelet transfusions (n = 43) and categorized into four clinical study groups or included in a non-transfused control group (n = 10). In total, 54 transfusions were included. No transfusion-mediated complement activation was observed. The transfusions were associated with a significant increase in the concentration of soluble P-selectin (p < .001), primarily corresponding to the passive infusion of soluble P-selectin-containing plasma residuals. The Δconcentration of soluble P-selectin was, however, not significantly correlated with the corrected count increments. Thus, significant correlations between biomarkers of complement and platelet activation and the post-transfusion platelet response could not be demonstrated in this study.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Platelets
volume
33
issue
3
pages
350 - 359
publisher
Taylor & Francis
external identifiers
  • pmid:34210243
  • scopus:85109397764
ISSN
1369-1635
DOI
10.1080/09537104.2021.1942817
language
English
LU publication?
yes
id
87cd5e76-bbfc-4ede-a31d-ebb6ea3d1a28
date added to LUP
2021-07-08 15:42:58
date last changed
2024-11-17 06:06:03
@article{87cd5e76-bbfc-4ede-a31d-ebb6ea3d1a28,
  abstract     = {{<p>Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of platelet concentrates. In this study, the post-transfusion platelet response, as indicated by the corrected count increment at 1 and 24 h after prophylactic platelet transfusions, respectively, was correlated with the 1 h post-transfusion Δconcentration (1 h post-transfusion - pretransfusion) of complement and platelet activation biomarkers. The study was registered as a clinical trial at ClinicalTrials.gov (identifier: NCT02601131) and patients were recruited during inpatient care in the hematological department. Soluble terminal complement complexes, soluble P-selectin and soluble CD40 ligand were analyzed. Confirmed alloimmunized patients were excluded. Included subjects were either given platelet transfusions (n = 43) and categorized into four clinical study groups or included in a non-transfused control group (n = 10). In total, 54 transfusions were included. No transfusion-mediated complement activation was observed. The transfusions were associated with a significant increase in the concentration of soluble P-selectin (p &lt; .001), primarily corresponding to the passive infusion of soluble P-selectin-containing plasma residuals. The Δconcentration of soluble P-selectin was, however, not significantly correlated with the corrected count increments. Thus, significant correlations between biomarkers of complement and platelet activation and the post-transfusion platelet response could not be demonstrated in this study.</p>}},
  author       = {{Åkesson, Alexander and Ljungkvist, Marcus and Martin, Myriam and Blom, Anna M and Klintman, Jenny and Schött, Ulf and Zetterberg, Eva and Kander, Thomas}},
  issn         = {{1369-1635}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{350--359}},
  publisher    = {{Taylor & Francis}},
  series       = {{Platelets}},
  title        = {{Biomarkers of complement and platelet activation are not correlated with the one or twenty-four hours corrected count increments in prophylactically platelet transfused hematological patients : a prospective cohort study}},
  url          = {{http://dx.doi.org/10.1080/09537104.2021.1942817}},
  doi          = {{10.1080/09537104.2021.1942817}},
  volume       = {{33}},
  year         = {{2022}},
}