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The effect of natural biomolecules on yttrium oxide nanoparticles from a Daphnia magna survival rate perspective

Kelpsiene, Egle LU ; Chang, Tingru ; Khort, Aliaksandr ; Bernfur, Katja LU ; Odnevall, Inger ; Cedervall, Tommy LU and Hua, Jing LU (2023) In Nanotoxicology 17(4). p.385-399
Abstract

The attention to rare earth oxide nanoparticles (NPs), including yttrium oxide (Y2O3), has increased in many fields due to their unique structural characteristics and functional properties. The aim of our study was to investigate the mechanisms by which bio-corona formation on Y2O3 NPs affects their environmental fate and toxicity. The Y2O3 NPs induced toxicity to freshwater filter feeder Daphnia magna at particle concentrations of 1 and 10 mg/L, regardless of particle size. Interactions between naturally excreted biomolecules (e.g. protein, lipids, and polysaccharides) derived from D. magna, and the Y2O3 NPs (30–45 nm) resulted in the formation of... (More)

The attention to rare earth oxide nanoparticles (NPs), including yttrium oxide (Y2O3), has increased in many fields due to their unique structural characteristics and functional properties. The aim of our study was to investigate the mechanisms by which bio-corona formation on Y2O3 NPs affects their environmental fate and toxicity. The Y2O3 NPs induced toxicity to freshwater filter feeder Daphnia magna at particle concentrations of 1 and 10 mg/L, regardless of particle size. Interactions between naturally excreted biomolecules (e.g. protein, lipids, and polysaccharides) derived from D. magna, and the Y2O3 NPs (30–45 nm) resulted in the formation of an eco-corona, which reduced their toxic effects toward D. magna at a particle concentration of 10 mg/L. No effects were observed at lower concentrations or for the other particle sizes investigated. Copper-zinc (Cu-Zn) superoxide dismutase, apolipophorins, and vitellogenin-1 proteins proved to be the most prominent proteins of the adsorbed corona, and possibly a reason for the reduced toxicity of the 30–45 nm Y2O3 NPs toward D. magna.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Daphnia magna, metallic nanoparticles, natural biomolecules; biocorona, yttrium oxide nanoparticles
in
Nanotoxicology
volume
17
issue
4
pages
15 pages
publisher
Informa Healthcare
external identifiers
  • pmid:37428876
  • scopus:85164704555
ISSN
1743-5390
DOI
10.1080/17435390.2023.2226712
language
English
LU publication?
yes
id
87ceaffc-cf07-496e-9766-de05a9db7f5f
date added to LUP
2023-08-10 08:24:45
date last changed
2024-04-20 00:14:29
@article{87ceaffc-cf07-496e-9766-de05a9db7f5f,
  abstract     = {{<p>The attention to rare earth oxide nanoparticles (NPs), including yttrium oxide (Y<sub>2</sub>O<sub>3</sub>), has increased in many fields due to their unique structural characteristics and functional properties. The aim of our study was to investigate the mechanisms by which bio-corona formation on Y<sub>2</sub>O<sub>3</sub> NPs affects their environmental fate and toxicity. The Y<sub>2</sub>O<sub>3</sub> NPs induced toxicity to freshwater filter feeder Daphnia magna at particle concentrations of 1 and 10 mg/L, regardless of particle size. Interactions between naturally excreted biomolecules (e.g. protein, lipids, and polysaccharides) derived from D. magna, and the Y<sub>2</sub>O<sub>3</sub> NPs (30–45 nm) resulted in the formation of an eco-corona, which reduced their toxic effects toward D. magna at a particle concentration of 10 mg/L. No effects were observed at lower concentrations or for the other particle sizes investigated. Copper-zinc (Cu-Zn) superoxide dismutase, apolipophorins, and vitellogenin-1 proteins proved to be the most prominent proteins of the adsorbed corona, and possibly a reason for the reduced toxicity of the 30–45 nm Y<sub>2</sub>O<sub>3</sub> NPs toward D. magna.</p>}},
  author       = {{Kelpsiene, Egle and Chang, Tingru and Khort, Aliaksandr and Bernfur, Katja and Odnevall, Inger and Cedervall, Tommy and Hua, Jing}},
  issn         = {{1743-5390}},
  keywords     = {{Daphnia magna; metallic nanoparticles; natural biomolecules; biocorona; yttrium oxide nanoparticles}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{385--399}},
  publisher    = {{Informa Healthcare}},
  series       = {{Nanotoxicology}},
  title        = {{The effect of natural biomolecules on yttrium oxide nanoparticles from a<i> Daphnia magna</i> survival rate perspective}},
  url          = {{http://dx.doi.org/10.1080/17435390.2023.2226712}},
  doi          = {{10.1080/17435390.2023.2226712}},
  volume       = {{17}},
  year         = {{2023}},
}